| Species |
Mouse |
| Protein Construction |
GUCY2C/Guanylyl cyclase C (Val20-Met433)
Accession # Q3UWA6-1 |
His |
Avi |
| N-term |
|
C-term |
|
| Conjugate |
Biotin |
| Purity |
> 95% as determined by Bis-Tris PAGE
> 90% as determined by HPLC |
| Endotoxin Level |
Less than 1EU per μg by the LAL method. |
| Expression System |
HEK293 |
| Theoretical Molecular Weight |
50.01 kDa |
| Apparent Molecular Weight |
Due to glycosylation, the protein migrates to 70-100 kDa based on Bis-Tris PAGE result. |
| Formulation |
Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4 . |
| Reconstitution |
It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 μg/ml. |
| Storage & Stability |
Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
![GUCY2C/Guanylyl Cyclase C[Biotin], His & Avi, Mouse](/product/documents/down?doc_name=Z03916 SEC-HPLC.png&file=scm_files/productFile_notes/2025/03/12/Z03916 SEC-HPLC.png "GUCY2C/Guanylyl Cyclase C[Biotin], His & Avi, Mouse")
The purity of GUCY2C/Guanylyl cyclase C[Biotin], His & Avi, Mouse is greater than 90% as determined by SEC-HPLC.
![GUCY2C/Guanylyl Cyclase C[Biotin], His & Avi, Mouse](/product/documents/down?doc_name=Z03916 PAGE.png&file=scm_files/productFile_notes/2025/03/12/Z03916 PAGE.png "GUCY2C/Guanylyl Cyclase C[Biotin], His & Avi, Mouse")
GUCY2C/Guanylyl cyclase C[Biotin], His & Avi, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
| Target Background |
Guanylyl cyclase C (GUCY2C) has canonical centrality in defense of key intestinal homeostatic mechanisms, encompassing fluid and electrolyte balance, epithelial dynamics, antitumorigenesis, and intestinal barrier function. GUCY2C may represent a new target for anti-obesity pharmacotherapy. |
| Synonyms |
Guanylyl cyclase C; GC-C; STAR; GUCY2C; GUC2C; STA receptor; DIAR6; EC 4.6.1; GCC; GUC2CEC 4.6.1.2; MUCIL |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
