Immobilized Anti-DLL3 Antibody, hFc Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for DLL3[Biotin], His, Human with the EC50 of 18.5 ng/ml determined by ELISA.

Biotinylated DLL3[Biotin], His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

DLL3[Biotin], His, Human

Delta-like protein 3 (DLL3) is a transmembrane protein that belongs to the Delta/Serrate/Lag-2 (DSL) family of Notch ligands. DLL3 inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity).

产品编号	Z03944
规格	100 μg 500 μg 大单询价
数量
价格	￥5700


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产品简介

Species

Human

Protein Construction

His	DLL3 (Ala27-Arg490) Accession # Q9NYJ7-1
N-term	C-term

Conjugate

Biotin

Purity

> 95% as determined by Bis-Tris PAGE

Endotoxin Level

Less than 1EU per μg by the LAL method.

Biological Activity

Immobilized Anti-DLL3 Antibody, hFc Tag at 2 μg/ml (100μl/Well) on the plate can bind DLL3[Biotin], His, Human (Cat.No.: Z03944)

Expression System

HEK293

Theoretical Molecular Weight

50.4 kDa

Apparent Molecular Weight

Due to glycosylation, the protein migrates to 52-60 kDa based on Bis-Tris PAGE result.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS, 200 mM L-Arginine (pH 7.4).

Reconstitution

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O more than 100 μg/ml.

Storage & Stability

Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

图例

Immobilized Anti-DLL3 Antibody, hFc Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for DLL3[Biotin], His, Human with the EC50 of 18.5 ng/ml determined by ELISA.

Biotinylated DLL3[Biotin], His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

技术背景

Target Background	Delta-like ligand 3 (DLL3) is an inhibitory Notch ligand. It is highly expressed on the surface of Small cell lung cancer (SCLC) and other neuroendocrine tumors. And its expression promotes SCLC migration and invasion. DLL3 agents are evaluated in several ongoing clinical studies in SCLC and other neuroendocrine tumors.
Synonyms	Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.