VEGF R1/FLT-1, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Immobilized VEGF R1/FLT-1, His & Avi, Human at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human VEGF121, His Tag with the EC50 of 24.4 ng/ml determined by ELISA.

VEGF R1/FLT-1, His&Avi, Human

VEGFR1 (vascular endothelial growth factor receptor 1), also called Flt-1 (Fms-like tyrosine kinase), is a 180 kDa type I transmembrane glycoprotein in the class III subfamily of receptor tyrosine kinases (RTKs).yrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis, and cancer cell invasion. May play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells.

产品编号	Z03964
规格	100 μg 500 μg 大单询价
数量
价格	￥3000


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产品简介

Species

Human

Protein Construction

VEGF R1/FLT-1 (Ser27-Asn756) Accession # P17948-1	His	Avi
N-term		C-term

Purity

> 95% as determined by Bis-Tris PAGE

Endotoxin Level

Less than 1EU per μg by the LAL method.

Biological Activity

Immobilized VEGF R1/FLT-1, His&Avi, Human (Cat.No.: Z03964) 2 μg/ml (100μl/well) on the plate can bind Biotinylated Human VEGF121, His Tag

Expression System

HEK293

Theoretical Molecular Weight

85.1 kDa

Apparent Molecular Weight

Due to glycosylation, the protein migrates to 100-120 kDa based on Bis-Tris PAGE result.

Formulation

Lyophilized from a 0.22 μm filtered solution in PBS, (pH 7.4).

Reconstitution

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O more than 100 μg/ml.

Storage & Stability

Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

图例

VEGF R1/FLT-1, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Immobilized VEGF R1/FLT-1, His & Avi, Human at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Biotinylated Human VEGF121, His Tag with the EC50 of 24.4 ng/ml determined by ELISA.

技术背景

Target Background	Vascular endothelial growth factor receptor 1(VEGFR1), also known as Flt-1, is a type I transmembrane glycoprotein of receptor tyrosine kinases (RTKs) family. VEGFR1 acts as a cell-surface receptor for VEGFA, VEGFB and PGF. It plays an important role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration and cancer cell invasion.
Synonyms	FLT; FLT1; Flt-1; FRT; VEGF R1; VEGFR1

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.