| Species |
Human |
| Protein Construction |
| Avi |
His |
CXCL4 (Glu32-Ser101)
Accession # NP_002610.1 |
| N-term |
|
C-term |
|
| Conjugate |
Biotin |
| Purity |
> 95% as determined by Bis-Tris PAGE |
| Endotoxin Level |
Less than 1EU per μg by the LAL method. |
| Biological Activity |
Measured by its binding ability in a functional ELISA. Immobilized Human CCL5, His Tag at 5μg/ml (100μl/well) on the plate can bind CXCL4[Biotin], His & Avi, Human. Test result was comparable to standard batch. |
| Expression System |
E.coli |
| Theoretical Molecular Weight |
10.68 kDa |
| Apparent Molecular Weight |
The protein migrates to 13 kDa based on Bis-Tris PAGE result. |
| Formulation |
Lyophilized from 0.22μm filtered solution in 4mM HCl (pH 3.0). |
| Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 4mM HCl (pH 3.0). |
| Storage & Stability |
Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Target Background |
Chemokines regulate leukocyte migration during physiological and pathological conditions. It is currently accepted that these chemotactic cytokines are also important in the development and progression of cancer. CXCL4 and its non-allelic variant CXCL4L1 are two platelet-associated chemokines that have been attributed anti-tumoral activity as a result of their angiostatic potential and the chemotactic activity for anti-tumoral leukocytes. |
| Synonyms |
PF-4; Oncostatin-A; CXCL4; SCYB4; Iroplact; MGC138298 |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
