| Species |
Human |
| Protein Construction |
NMNAT1(Met1-Thr279)
Accession # Q9HAN9 |
His |
| N-term |
C-term |
|
| Purity |
> 95% as determined by BisTris PAGE
> 90% as determined by HPLC |
| Endotoxin Level |
Less than 1EU per μg by the LAL method. |
| Expression System |
Baculovirus-Insect Cells(Sf9) |
| Theoretical Molecular Weight |
33.46 kDa |
| Apparent Molecular Weight |
The protein has a predicted MW of 33.46 kDa same as Bis-Tris PAGE result. |
| Formulation |
Lyophilized from 0.22μm filtered solution in 20mM Tris, 500mM NaCl, 3mM DTT (pH 7.5). |
| Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage & Stability |
Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Target Background |
Nicotinamide mononucleotide adenylyltransferease (NMNAT), a rate-limiting enzyme present in all organisms, reversibly catalyzes the important step in the biosynthesis of NAD from ATP and NMN. NMNAT also catalyzes the metabolic conversion of potent antitumor prodrugs like tiazofurin and benzamide riboside to their active forms which are analogs of NAD. |
| Synonyms |
NMNAT; LCA9; PNAT1 |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
