| Species |
Human |
| Protein Construction |
TIM-1/HAVCR1 (Ser21-Gly295)_x000D_
Accession # Q96D42 |
His |
| N-term |
C-term |
|
| Purity |
> 95% as determined by BisTris PAGE
> 95% as determined by HPLC |
| Endotoxin Level |
Less than 1EU per μg by the LAL method. |
| Expression System |
HEK293 |
| Theoretical Molecular Weight |
30.58 kDa |
| Apparent Molecular Weight |
Due to glycosylation, the protein migrates to 95-115 kDa based on Bis-Tris PAGE result. |
| Formulation |
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). |
| Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage & Stability |
Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Target Background |
Kidney injury molecule 1 (KIM-1, also known as TIM-1) is markedly upregulated in the proximal tubule after injury and is maladaptive when chronically expressed. KIM-1-mediated epithelial cell phagocytosis of apoptotic cells protects the kidney after acute injury by downregulating innate immunity and inflammation. |
| Synonyms |
HAVcr-1; KIM-1; KIM1; TIMD-1; TIMD1;TIM; TIM-1; TIM1; CD365; HAVCR1; HAVCR; HAVCR-1 |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
