| Species |
Mouse |
| Protein Construction |
Integrin alpha L beta 2 (ITGAL&ITGB2) Heterodimer[Tyr24-His1087 (ITGAL) acidic tail & Gln24-Asn702 (ITGB2) basic tail]
Accession # P24063-1(ITGAL)&P11835(ITGB2) |
His |
| N-term |
C-term |
|
| Purity |
> 95% as determined by BisTris PAGE
> 95% as determined by HPLC |
| Endotoxin Level |
Less than 1EU per μg by the LAL method. |
| Expression System |
HEK293 |
| Theoretical Molecular Weight |
123.30 kDa (ITGAL) and 79.60 kDa (ITGB2) |
| Apparent Molecular Weight |
Due to glycosylation, the protein migrates to 160-180 kDa (ITGAL) and 90-105 kDa (ITGB2) based on Bis-Tris PAGE result. |
| Formulation |
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). |
| Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Storage & Stability |
Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles. |
| Target Background |
Integrin αLβ2 is one member of the integrin family and also called leukocyte function-associated antigen-1 (LFA-1). It is widely expressed on T lymphocytes and controls the function and, in particular, the migration of immune cells[1]. Active αLβ2 can bind ICAM1/CD54, ICAM2, ICAM3 and JAM1[2]. |
| Synonyms |
αLβ2; ITGAL&ITGB2; ITGAL; ITGB2 |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
