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Metal binding and interdomain thermodynamics of mammalian metallothionein-3: enthalpically favoured Cu supplants entropically favoured Zn to form Cu clusters under physiological conditions
Authors: Matthew R Mehlenbacher, Rahma Elsiesy, Rabina Lakha, Rhiza Lyne E Villones, Marina Orman, Christina L Vizcarra, Gabriele Meloni, Dean E Wilcox, Rachel N Austin
Journal: Chem Sci
PubMed ID: 35655557
Doi: 10.1039/d2sc00676f
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TFPIisacoloniccryptreceptorforTcdBfromhypervirulentclade2C.difficile
Authors: Jianhua Luo , Qi Yang , Xiaofeng Zhang , Yuanyuan Zhang , Li Wan , Xiechao Zhan , Yao Zhou , Liuqing He , Danyang Li , Dazhi Jin , Ying Zhen , Jing Huang , Yanyan Li , Liang Tao
Journal: Cell
PubMed ID: 35303428
Doi: 10.1016/j.cell.2022.02.010
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A scalable serology solution for profiling humoral immune responses to SARS-CoV-2 infection and vaccination
Authors: Karen Colwill, Yannick Galipeau, Matthew Stuible, Christian Gervais, Corey Arnold, Bhavisha Rathod, Kento T Abe, Jenny H Wang, Adrian Pasculescu, Mariam Maltseva, Lynda Rocheleau, Martin Pelchat, Mahya Fazel-Zarandi, Mariam Iskilova, Miriam Barrios-Rodiles, Linda Bennett, Kevin Yau, François Cholette, Christine Mesa, Angel X Li, Aimee Paterson, Michelle A Hladunewich, Pamela J Goodwin, Jeffrey L Wrana, Steven J Drews, Samira Mubareka, Allison J McGeer, John Kim, Marc-André Langlois, Anne-Claude Gingras, Yves Durocher
Journal: Clin Transl Immunology
PubMed ID: 35356067
Doi: 10.1002/cti2.1380
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A peroxisomal heterodimeric enzyme is involved in benzaldehyde synthesis in plants
Authors: Xing-Qi Huang, Renqiuguo Li, Jianxin Fu, Natalia Dudareva
Journal: Nat Commun
PubMed ID: 35292635
Doi: 10.1038/s41467-022-28978-2
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Human antibody recognizing a quaternary epitope in the Puumala virus glycoprotein provides broad protection against orthohantaviruses
Authors: Eva Mittler, Anna Z Wec, Janne Tynell, Pablo Guardado-Calvo, Julia Wigren-Byström, Laura C Polanco, Cecilia M O'Brien, Megan M Slough, Dafna M Abelson, Alexandra Serris, Mrunal Sakharkar, Gerard Pehau-Arnaudet, Russell R Bakken, James C Geoghegan, Rohit K Jangra, Markus Keller, Larry Zeitlin, Olli Vapalahti, Rainer G Ulrich, Zachary A Bornholdt, Clas Ahlm, Felix A Rey, John M Dye, Steven B Bradfute, Tomas Strandin, Andrew S Herbert, Mattias N E Forsell, Laura M Walker, Kartik Chandran
Journal: Sci Transl Med
PubMed ID: 35294259
Doi: 10.1126/scitranslmed.abl5399
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Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor
Authors: Haozhou Tan, Chunlong Ma, Jun Wang
Journal: Res Sq
PubMed ID: 35378761
Doi: 10.21203/rs.3.rs-1490282/v1
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Glycosite-deleted mRNA of SARS-CoV-2 spike protein as a broad-spectrum vaccine
Authors: Chung-Yi Wu, Cheng-Wei Cheng, Chih-Chuan Kung, Kuo-Shiang Liao, Jia-Tsrong Jan, Che Ma, Chi-Huey Wong
Journal: Proc Natl Acad Sci U S A
PubMed ID: 35149556
Doi: 10.1073/pnas.2119995119
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Engineering Saccharomyces cerevisiae for the production and secretion of Affibody molecules
Authors: Veronica Gast, Anna Sandegren, Finn Dunås, Siri Ekblad, Rezan Güler, Staffan Thorén, Marta Tous Mohedano, Mikael Molin, Martin K M Engqvist, Verena Siewers
Journal: Microb Cell Fact
PubMed ID: 35264156
Doi: 10.1186/s12934-022-01761-0
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Metabolic engineering of Saccharomyces cerevisiae for gram-scale diosgenin production
Authors: Liping Xu , Dong Wang , Jing Chen , Bo Li , Qingyan Li , Pingping Liu , Ying Qin , Zhubo Dai , Feiyu Fan , Xueli Zhang
Journal: Metab Eng
PubMed ID: 35085779
Doi: 10.1016/j.ymben.2022.01.013
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Ligation-assisted homologous recombination enables precise genome editing by deploying both MMEJ and HDR
Authors: Zhihan Zhao, Peng Shang, Fanny Sage, Niels Geijsen
Journal: Nucleic Acids Res
PubMed ID: 35212386
Doi: 10.1093/nar/gkac118
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