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Deep mutational scanning reveals a correlation between degradation and toxicity of thousands of aspartoacylase variants
Authors: Martin Grønbæk-Thygesen, Vasileios Voutsinos, Kristoffer E. Johansson, Thea K. Schulze, Matteo Cagiada, Line Pedersen, Lene Clausen, Snehal Nariya, Rachel L. Powell, Amelie Stein, Douglas M. Fowler, Kresten Lindorff-Larsen & Rasmus Hartmann-Petersen
Journal: Nat Commun
PubMed ID: 38740822
Doi: 10.1038/s41467-024-48481-0
Products & Services: Mutagenesis Services   
Helicases DDX5 and DDX17 promote heterogeneity in HBV transcription termination in infected human hepatocytes
Authors: Fleur Chapus 1, Guillaume Giraud 2, Pélagie Huchon 3, Mélanie Rodà 2, Xavier Grand 2, Caroline Charre 4, Chloé Goldsmith 5, Armando Andres Roca Suarez 2, Maria-Guadalupe Martinez 1, Judith Fresquet 6, Audrey Diederichs 3, Maëlle Locatelli 1, Hélène Polvèche 7, Caroline Scholtès 8, Isabelle Chemin 2, Hector Hernandez Vargas 5, Michel Rivoire 9, Cyril F Bourgeois 10, Fabien Zoulim 11, Barbara Testoni 12
Journal: J Hepatol
PubMed ID: 38782119
Doi: doi: 10.1016/j.jhep.2024.05.016.
Products & Services: Mutagenesis Services   
The new missense G376V-TDP-43 variant induces late-onset distal myopathy but not amyotrophic lateral sclerosis
Authors: Julia Zibold, Lola E R Lessard, Flavien Picard, Lara Gruijs da Silva, Yelyzaveta Zadorozhna, Nathalie Streichenberger, Edwige Belotti, Alexis Osseni, Andréa Emerit, Elisabeth Errazuriz-Cerda, Laurence Michel-Calemard, Rita Menassa, Laurent Coudert, Manuela Wiessner, Rolf Stucka, Thomas Klopstock, Francesca Simonetti, Saskia Hutten, Takashi Nonaka, Masato Hasegawa, Tim M Strom, Emilien Bernard, Elisabeth Ollagnon, Andoni Urtizberea, Dorothee Dormann, Philippe Petiot, Laurent Schaeffer, Jan Senderek, Pascal Leblanc
Journal: Brain
PubMed ID: 38079474
Doi: 10.1093/brain/awad410
Products & Services: Mutagenesis Services   
The translocation of a chloride channel from the Golgi to the plasma membrane helps plants adapt to salt stress
Authors: Sivamathini Rajappa, Pannaga Krishnamurthy, Hua Huang, Dejie Yu, Jiří Friml, Jian Xu & Prakash P. Kumar
Journal: Nat Commun
PubMed ID: 38729926
Doi: 10.1038/s41467-024-48234-z
Products & Services: Mutagenesis Services   
pH-dependent regulation of an acidophilic -acetylhomoserine sulfhydrylase from
Authors: Yasuyuki Matoba, Kosuke Oda, Maho Wataeda, Hina Kanemori, Koichi Matsuo
Journal: Appl Environ Microbiol
PubMed ID: 38568076
Doi: 10.1128/aem.00118-24
Products & Services: Mutagenesis Services   
Structural basis for the minimal bifunctional alginate epimerase AlgE3 from Azotobacter chroococcum
Authors: Takaaki Fujiwara, Eriko Mano, Eriko Nango
Journal: FEBS Lett
PubMed ID: 38649293
Doi: 10.1002/1873-3468.14886
Products & Services: Mutagenesis Services   
Coordination of actin plus-end dynamics by IQGAP1, formin, and capping protein
Authors: Morgan L Pimm, Brian K Haarer, Alexander D Nobles, Laura M Haney, Alexandra G Marcin, Jessica L Henty-Ridilla
Journal: biorxiv
PubMed ID: 37205555
Doi: 10.1101/2023.05.04.539490
Products & Services: Mutagenesis Services   
Exploring the enigmatic association between PNLIP variants and risk of chronic pancreatitis in a large Chinese cohort
Authors: Brett M Cassidy, Fei Jiang, Jianguo Lin, Jian-Min Chen, Grace E Curry, Guo-Xiu Ma, Steven J Wilhelm, Shun-Jiang Deng, Guoying Zhu, Zhuan Liao, Mark E Lowe, Xunjun K Xiao, Wen-Bin Zou
Journal: Pancreatology
PubMed ID: 38485544
Doi: 10.1016/j.pan.2024.03.002
Products & Services: Mutagenesis Services   
G-quadruplexes control hepatitis B virus replication by promoting cccDNA transcription and phase separation in hepatocytes
Authors: Guillaume Giraud, Mélanie Rodà, Pélagie Huchon, Maud Michelet, Sarah Maadadi, Daniel Jutzi, Roland Montserret, Marc-David Ruepp, Romain Parent, Christophe Combet, Fabien Zoulim, Barbara Testoni
Journal: Nucleic Acids Res
PubMed ID: 38113270
Doi: 10.1093/nar/gkad1200
Products & Services: Mutagenesis Services   
FANCJ promotes PARP1 activity during DNA replication that is essential in BRCA1 deficient cells
Authors: Ke Cong, Nathan MacGilvary, Silviana Lee, Shannon G MacLeod, Jennifer Calvo, Min Peng, Arne Nedergaard Kousholt, Tovah A Day, Sharon B Cantor
Journal: Nat Commun
PubMed ID: 38521768
Doi: 10.1038/s41467-024-46824-5
Products & Services: Mutagenesis Services   

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