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Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2
Authors: Juliana C Ferreira, Samar Fadl, Wael M Rabeh
Journal: J Biol Chem
PubMed ID: 35568197
Doi: 10.1016/j.jbc.2022.102023
Products & Services: Mutant Libraries   
The Toxoplasma glucan phosphatase TgLaforin utilizes a distinct functional mechanism that can be exploited by therapeutic inhibitors
Authors: Robert D Murphy, Tiantian Chen, Jianping Lin, Rongjun He, Li Wu, Caden R Pearson, Savita Sharma, Carl D Vander Kooi, Anthony P Sinai, Zhong-Yin Zhang, Craig W Vander Kooi, Matthew S Gentry
Journal: J Biol Chem
PubMed ID: 35640720
Doi: 10.1016/j.jbc.2022.102089
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Tau R2 and R3 are essential regions for tau aggregation, seeding and propagation
Authors: Narendran Annadurai, Lukáš Malina, Jakub Malohlava, Marián Hajdúch, Viswanath Das
Journal: Biochimie
PubMed ID: 35623497
Doi: 10.1016/j.biochi.2022.05.013
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The structural basis of Cdc7-Dbf4 kinase dependent targeting and phosphorylation of the MCM2-7 double hexamer
Authors: Almutasem Saleh, Yasunori Noguchi, Ricardo Aramayo, Marina E Ivanova, Kathryn M Stevens, Alex Montoya, S Sunidhi, Nicolas Lopez Carranza, Marcin J Skwark, Christian Speck
Journal: Nat Commun
PubMed ID: 35614055
Doi: 10.1038/s41467-022-30576-1
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Structural Insights on the Conversion of Cytochrome P450 to P420
Authors: Jessica A Gable, Sarvind Tripathi, Thomas L Poulos
Journal: ACS Omega
PubMed ID: 35694512
Doi: 10.1021/acsomega.2c00960
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Identification of Phosphorylation and Other Post-Translational Modifications in the Central C4C5 Domains of Murine Cardiac Myosin Binding Protein C
Authors: Chang Yoon Doh, Katherine L Dominic, Caitlin E Swanberg, Nikhil Bharambe, Belinda B Willard, Ling Li, Rajesh Ramachandran, Julian E Stelzer
Journal: ACS Omega
PubMed ID: 35573219
Doi: 10.1021/acsomega.2c00799
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Metabolic engineering of yeasts for green and sustainable production of bioactive ginsenosides F2 and 3,20-Di--Glc-DM
Authors: Fenglin Jiang, Chen Zhou, Yan Li, Haidong Deng, Ting Gong, Jingjing Chen, Tianjiao Chen, Jinling Yang, Ping Zhu
Journal: Acta Pharm Sin B
PubMed ID: 35865098
Doi: 10.1016/j.apsb.2022.04.012
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Characterization of Genetic Variants of Uncertain Significance for the Gene in Patients With Adult Hypophosphatasia
Authors: Raquel Sanabria-de la Torre, Luis Martínez-Heredia, Sheila González-Salvatierra, Francisco Andújar-Vera, Iván Iglesias-Baena, Juan Miguel Villa-Suárez, Victoria Contreras-Bolívar, Mario Corbacho-Soto, Gonzalo Martínez-Navajas, Pedro J Real, Cristina García-Fontana, Manuel Muñoz-Torres, Beatriz García-Fontana
Journal: Front Endocrinol (Lausanne)
PubMed ID: 35498405
Doi: 10.3389/fendo.2022.863940
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The Copper Resistome of Group B Streptococcus Reveals Insight into the Genetic Basis of Cellular Survival during Metal Ion Stress
Authors: Kelvin G K Goh, Matthew J Sullivan, Glen C Ulett
Journal: J Bacteriol
PubMed ID: 35404113
Doi: 10.1128/jb.00068-22
Products & Services: Mutant Libraries   
Insights into the inhibition of type I-F CRISPR-Cas system by a multifunctional anti-CRISPR protein AcrIF24
Authors: Lingguang Yang, Laixing Zhang, Peipei Yin, Hao Ding, Yu Xiao, Jianwei Zeng, Wenhe Wang, Huan Zhou, Qisheng Wang, Yi Zhang, Zeliang Chen, Maojun Yang, Yue Feng
Journal: Nat Commun
PubMed ID: 35411005
Doi: 10.1038/s41467-022-29581-1
Products & Services: Mutant Libraries   

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