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The Recurrent Mutation in PATL2 Inhibits Its Degradation Thus Causing Female Infertility Characterized by Oocyte Maturation Defect Through Regulation of the Mos-MAPK Pathway
Authors: Qiqi Cao, Chun Zhao, Congjing Wang, Lingbo Cai, Meng Xia, Xiaolan Zhang, Jian Han, Yangyang Xu, Junqiang Zhang, Xiufeng Ling, Xiang Ma, Ran Huo
Journal: Front Cell Dev Biol
PubMed ID: 33614659
Doi: 10.3389/fcell.2021.628649
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The one-carbon pool controls mitochondrial energy metabolism via complex I and iron-sulfur clusters
Authors: Florian A Schober, David Moore, Ilian Atanassov, Marco F Moedas, Paula Clemente, Ákos Végvári, Najla El Fissi, Roberta Filograna, Anna-Lena Bucher, Yvonne Hinze, Matthew The, Erik Hedman, Ekaterina Chernogubova, Arjana Begzati, Rolf Wibom, Mohit Jain, Roland Nilsson, Lukas Käll, Anna Wedell, Christoph Freyer, Anna Wredenberg
Journal: Sci Adv
PubMed ID: 33608280
Doi: 10.1126/sciadv.abf0717
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VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism
Authors: Yu-Hsuan Chen, Tzu-Yu Huang, Yu-Tung Lin, Shu-Yu Lin, Wen-Hsin Li, Hsiang-Jung Hsiao, Ruei-Liang Yan, Hong-Wen Tang, Zhao-Qing Shen, Guang-Chao Chen, Kuen-Phon Wu, Ting-Fen Tsai, Ruey-Hwa Chen
Journal: Nat Commun
PubMed ID: 33637724
Doi: 10.1038/s41467-021-21715-1
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Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors
Authors: Chris A Brosey, Jerry H Houl, Panagiotis Katsonis, Lakshitha P F Balapiti-Modarage, Shobanbabu Bommagani, Andy Arvai, Davide Moiani, Albino Bacolla, Todd Link, Leslie S Warden, Olivier Lichtarge, Darin E Jones, Zamal Ahmed, John A Tainer
Journal: Prog Biophys Mol Biol
PubMed ID: 33636189
Doi: 10.1016/j.pbiomolbio.2021.02.002
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Self-assembly and regulation of protein cages from pre-organised coiled-coil modules
Authors: Fabio Lapenta, Jana Aupič, Marco Vezzoli, Žiga Strmšek, Stefano Da Vela, Dmitri I Svergun, José María Carazo, Roberto Melero, Roman Jerala
Journal: Nat Commun
PubMed ID: 33574245
Doi: 10.1038/s41467-021-21184-6
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A dynein-associated photoreceptor protein prevents ciliary acclimation to blue light
Authors: Osamu Kutomi, Ryosuke Yamamoto, Keiko Hirose, Katsutoshi Mizuno, Yuuhei Nakagiri, Hiroshi Imai, Akira Noga, Jagan Mohan Obbineni, Noemi Zimmermann, Masako Nakajima, Daisuke Shibata, Misa Shibata, Kogiku Shiba, Masaki Kita, Hideo Kigoshi, Yui Tanaka, Yuya Yamasaki, Yuma Asahina, Chihong Song, Mami Nomura, Mamoru Nomura, Ayako Nakajima, Mia Nakachi, Lixy Yamada, Shiori Nakazawa, Hitoshi Sawada, Kazuyoshi Murata, Kaoru Mitsuoka, Takashi Ishikawa, Ken-Ichi Wakabayashi, Takahide Kon, Kazuo Inaba
Journal: Sci Adv
PubMed ID: 33637535
Doi: 10.1126/sciadv.abf3621
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A fusion transcription factor-driven cancer progresses to a fusion-independent relapse via constitutive activation of a downstream transcriptional target
Authors: Salah Boudjadi, Puspa Raj Pandey, Bishwanath Chatterjee, Thanh Hung Nguyen, Wenyue Sun, Frederic G Barr
Journal: Cancer Res
PubMed ID: 33589519
Doi: 10.1158/0008-5472.CAN-20-1613
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The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2
Authors: Sensen Zhang, Jun Zhou, Yuebin Zhang, Tianya Liu, Perrine Friedel, Wei Zhuo, Suma Somasekharan, Kasturi Roy, Laixing Zhang, Yang Liu, Xianbin Meng, Haiteng Deng, Wenwen Zeng, Guohui Li, Biff Forbush, Maojun Yang
Journal: Commun Biol
PubMed ID: 33597714
Doi: 10.1038/s42003-021-01750-w
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The kinetic landscape of an RNA-binding protein in cells
Authors: Deepak Sharma, Leah L Zagore, Matthew M Brister, Xuan Ye, Carlos E Crespo-Hernández, Donny D Licatalosi, Eckhard Jankowsky
Journal: Nature
PubMed ID: 33568810
Doi: 10.1038/s41586-021-03222-x
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Characterization of the sorbitol dehydrogenase SmoS from Sinorhizobium meliloti 1021
Authors: MacLean G Kohlmeier, Ben A Bailey-Elkin, Brian L Mark, Ivan J Oresnik
Journal: Acta Crystallogr D Struct Biol
PubMed ID: 33645541
Doi: 10.1107/S2059798321001017
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