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Metabolite-dependent m6A methylation driven by mechanotransduction-metabolism-epitranscriptomics axis promotes bone development and regeneration
Authors: Zhuo Li, Zhengnan Guo, Zhengmeng Yang, Boguang Yang, Yuan Hu, Xian Xie, Zhixian Zong, Zekun Chen, Kunyu Zhang, Pengchao Zhao, Gang Li, Xuefeng Yang, Liming Bian
Journal: Cell Rep
PubMed ID: 40272981
Doi: 10.1016/j.celrep.2025.115611
Products & Services: Peptide Synthesis   
Using Regular Porous Membrane-Based Blood−Brain Barrier Model to Screen Brain-Targeted Drugs with Nanochannel Electrochemistry
Authors: Yafeng Wu,Zixuan Chen,Fengxiang Chen,Juan Su,Jianyu Han,Songqin Liu
Journal: Anal Chem
PubMed ID: 40183921
Doi: 10.1021/acs.analchem.5c00365
Products & Services: Peptide Synthesis   
SUMO4 promotes SUMO deconjugation required for DNA double-strand-break repair
Authors: Alexander J Garvin, Alexander J Lanz, George E Ronson, Matthew J W Mackintosh, Katarzyna Starowicz, Alexandra K Walker, Yara Aghabi, Hannah MacKay, Ruth M Densham, Jai S Bhachoo, Aneika C Leney, Joanna R Morris
Journal: Mol Cell
PubMed ID: 40054443
Doi: 10.1016/j.molcel.2025.02.004
Deciphering molecular specificity in MCL-1/BAK interaction and its implications for designing potent MCL-1 inhibitors
Authors: Hudie Wei, Haolan Wang, Shuang Xiang, Jiaqi Wang, Lingzhi Qu, Xiaojuan Chen, Ming Guo, Xiaoyun Lu, Yongheng Chen
Journal: Cell Death Differ
PubMed ID: 39901037
Doi: 10.1038/s41418-025-01454-2
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Self-assembly GSH response based Buforin IIb-Olaparib nanocombination synergistically promotes DNA damage for prostate cancer immunotherapy
Authors: Maosong Hu , Yuyu Zhu , Xinyi Tang , Jing Xu , Hanbin Ma , Zhihan Chen , Duo Chen , Wenyuan Wu , Xialin Chen , Rongrong He , Jing Zhou , Jinao Duan , Weiguo Chen , Hongyue Ma
Journal: Chemical Engineering Journal
Doi: 10.1016/j.cej.2025.160862
Products & Services: Peptide Synthesis   
PSKH1 kinase activity is differentially modulated via allosteric binding of Ca2+ sensor proteins
Authors: Christopher R Horne, Toby A Dite, Samuel N Young, Lucy J Mather, Laura F Dagley, Jared L Johnson, Tomer M Yaron-Barir, Emily M Huntsman, Leonard A Daly, Dominic P Byrne, Antonia L Cadell, Boaz H Ng, Jumana Yousef, Dylan H Multari, Lianju Shen, Luke M McAloon, Gerard Manning, Mark A Febbraio, Anthony R Means, Lewis C Cantley, Maria C Tanzer, David R Croucher, Claire E Eyers, Patrick A Eyers, John W Scott, James M Murphy
Journal: Proc Natl Acad Sci U S A
PubMed ID: 39964718
Doi: 10.1073/pnas.2420961122
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Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK
Authors: Chang Peng, Haowen Jiang, Liya Jing, Wenhua Yang, Xiaotong Guan, Hanlin Wang, Sike Yu, Yutang Cao, Min Wang, Huan Ma, Zan Lv, Hongyu Gu, Chunmei Xia, Xiaozhen Guo, Bin Sun, Aili Wang, Cen Xie, Wenbiao Wu, Luyiyi Lu, Jiayi Song, Saifei Lei, Rui Wu, Yi Zang, Erjiang Tang, Jia Li
Journal: Nat Commun
PubMed ID: 39966410
Doi: 10.1038/s41467-025-57044-w
Products & Services: Peptide Synthesis   
Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson’s disease model mice
Authors: Wei Song, Zi-Ming Zhou, Le-le Zhang, Hai-Feng Shu, Jin-Ru Xia, Xia Qin, Rong Hua, Yong-Mei Zhang
Journal: Cell Death Dis
PubMed ID: 39809747
Doi: 10.1038/s41419-025-07333-5
Products & Services: Peptide Synthesis   
An Insect Effector Mimics Its Host Immune Regulator to Undermine Plant Immunity
Authors: Jianmei Fu , Shuai Li , Jing Li , Zhichang Zhao , Jing Li , Xinyang Tan , Shan Yu , Maofeng Jing , Keyan Zhu-Salzman , Jichao Fang , Rui Ji
Journal: Adv Sci (Weinh)
PubMed ID: 39853648
Doi: doi.org/10.1002/advs.202409186
Products & Services: Peptide Synthesis   
Dictating the spatial-temporal delivery of molecular adjuvant and antigen for the enhanced vaccination
Authors: Yumeng Yan , Xiaonan Huang , Lili Yuan , To Ngai , Guanghui Ma , Yufei Xia
Journal: Biomaterials
PubMed ID: 38968687
Doi: 10.1016/j.biomaterials.2024.122697
Products & Services: Peptide Synthesis   

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