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Preclinical evaluation of a plant-derived SARS-CoV-2 subunit vaccine: Protective efficacy, immunogenicity, safety, and toxicity

Authors: Balamurugan Shanmugaraj, Narach Khorattanakulchai, Chalisa Panapitakkul, Ashwini Malla, Rawiwan Im-Erbsin, Manutsanun Inthawong, Piyanate Sunyakumthorn, Taweewun Hunsawong, Chonticha Klungthong, Matthew C Reed, Taratorn Kemthong, Nutchanat Suttisan, Suchinda Malaivijitnond, Passaraporn Srimangkornkaew, Aekkarin Klinkhamhom, Suwimon Manopwisedjaroen, Arunee Thitithanyanont, Suthira Taychakhoonavudh, Waranyoo Phoolcharoen

Journal: Vaccine

PubMed ID: 35697573

Doi: 10.1016/j.vaccine.2022.05.087

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Rapid titration of recombinant baculoviruses based on NanoLuc secretion in early infection

Authors: Jige Li, Meng Xu, Juan Sun, Junjun Li, Jianqing Chen, Qin Chen, Jian Chen

Journal: J Virol Methods

PubMed ID: 35728698

Doi: 10.1016/j.jviromet.2022.114565

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CD137 Agonists Targeting CD137-Mediated Negative Regulation Show Enhanced Antitumor Efficacy in Lung Cancer

Authors: Ling Yi , Xin Jin , Jinghui Wang , Zhuohong Yan , Xu Cheng , Tao Wen , Bin Yang , Xiaojue Wang , Nanying Che , Zhidong Liu and Hongtao Zhang

Journal: Frontiers in Immunology

Doi: 10.3389/fimmu.2022.771809

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Induction of Th1 and Th2 in the protection against SARS-CoV-2 through mucosal delivery of an adenovirus vaccine expressing an engineered spike protein

Authors: Nai-Hsiang Chung, Ying-Chin Chen, Shiu-Ju Yang, Yu-Ching Lin, Horng-Yunn Dou, Lily Hui-Ching Wang, Ching-Len Liao, Yen-Hung Chow

Journal: Vaccine

PubMed ID: 34952759

Doi: 10.1016/j.vaccine.2021.12.024

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Kinetic proofreading of lipochitooligosaccharides determines signal activation of symbiotic plant receptors

Authors: Kira Gysel, Mette Laursen, Mikkel B Thygesen, Damiano Lironi, Zoltán Bozsóki, Christian T Hjuler, Nicolai N Maolanon, Jeryl Cheng, Peter K Bjørk, Maria Vinther, Lene H Madsen, Henriette Rübsam, Artur Muszyński, Arshia Ghodrati, Parastoo Azadi, John T Sullivan, Clive W Ronson, Knud J Jensen, Mickaël Blaise, Simona Radutoiu, Jens Stougaard, Kasper R Andersen

Journal: Proc Natl Acad Sci U S A

PubMed ID: 34716271

Doi: 10.1073/pnas.2111031118

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Nanoparticular CpG-adjuvanted SARS-CoV-2 S1 protein elicits broadly neutralizing and Th1-biased immunoreactivity in mice

Authors: Hui-Tsu Lin, Cheng-Cheung Chen, Der-Jiang Chiao, Tein-Yao Chang, Xin-An Chen, Jenn-Jong Young, Szu-Cheng Kuo

Journal: Int J Biol Macromol

PubMed ID: 34774590

Doi: 10.1016/j.ijbiomac.2021.11.020

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A mosquito AgTRIO monoclonal antibody reduces early infection of mice

Authors: Yu-Min Chuang, Xu-Dong Tang, Erol Fikrig

Journal: Infect Immun

PubMed ID: 34724388

Doi: 10.1128/IAI.00359-21

Products & Services: Insect Expression Monoclonal Antibody Services Peptide Synthesis

Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation

Authors: Eleonora Turco, Adriana Savova, Flora Gere, Luca Ferrari, Julia Romanov, Martina Schuschnig, Sascha Martens

Journal: Nat Commun

PubMed ID: 34471133

Doi: 10.1038/s41467-021-25572-w

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Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination

Authors: Matthew J Gorman, Nita Patel, Mimi Guebre-Xabier, Alex L Zhu, Caroline Atyeo, Krista M Pullen, Carolin Loos, Yenny Goez-Gazi, Ricardo Carrion, Jing-Hui Tian, Dansu Yuan, Kathryn A Bowman, Bin Zhou, Sonia Maciejewski, Marisa E McGrath, James Logue, Matthew B Frieman, David Montefiori, Colin Mann, Sharon Schendel, Fatima Amanat, Florian Krammer, Erica Ollmann Saphire, Douglas A Lauffenburger, Ann M Greene, Alyse D Portnoff, Michael J Massare, Larry Ellingsworth, Gregory Glenn, Gale Smith, Galit Alter

Journal: Cell Rep Med

PubMed ID: 34485950

Doi: 10.1016/j.xcrm.2021.100405

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Plant-Produced Receptor-Binding Domain of SARS-CoV-2 Elicits Potent Neutralizing Responses in Mice and Non-human Primates

Authors: Konlavat Siriwattananon, Suwimon Manopwisedjaroen, Balamurugan Shanmugaraj, Kaewta Rattanapisit, Supaporn Phumiamorn, Sompong Sapsutthipas, Sakalin Trisiriwanich, Eakachai Prompetchara, Chutitorn Ketloy, Supranee Buranapraditkun, Wassana Wijagkanalan, Kittipan Tharakhet, Papatsara Kaewpang, Kantinan Leetanasaksakul, Taratorn Kemthong, Nutchanat Suttisan, Suchinda Malaivijitnond, Kiat Ruxrungtham, Arunee Thitithanyanont, Waranyoo Phoolcharoen

Journal: Front Plant Sci

PubMed ID: 34054909

Doi: 10.3389/fpls.2021.682953

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