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AL101, a gamma-secretase inhibitor, has potent antitumor activity against adenoid cystic carcinoma with activated NOTCH signaling
Authors: Renata Ferrarotto, Vasudha Mishra, Elad Herz, Adar Yaacov, Oz Solomon, Rami Rauch, Adi Mondshine, Maria Motin, Tal Leibovich-Rivkin, Matti Davis, Joel Kaye, Christopher R Weber, Le Shen, Alexander T Pearson, Ari J Rosenberg, Xiangying Chen, Alka Singh, Jon C Aster, Nishant Agrawal, Evgeny Izumchenko
Journal: Cell Death Dis
PubMed ID: 35931701
Doi: 10.1038/s41419-022-05133-9
Products & Services: Mammalian Expression   
IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues
Authors: Anissa A Widjaja, Sonia Chothani, Sivakumar Viswanathan, Joyce Wei Ting Goh, Wei-Wen Lim, Stuart A Cook
Journal: Int J Mol Sci
PubMed ID: 36012165
Doi: 10.3390/ijms23168900
Products & Services: Mammalian Expression   
Biophysical characterization of light-gated ion channels using planar automated patch clamp
Authors: Elena G Govorunova, Oleg A Sineshchekov, Leonid S Brown, John L Spudich
Journal: Front Mol Neurosci
PubMed ID: 36017077
Doi: 10.3389/fnmol.2022.976910
Products & Services: Mammalian Expression   
Discovery and intranasal administration of a SARS-CoV-2 broadly acting neutralizing antibody with activity against multiple Omicron subvariants
Authors: J Andrew Duty, Thomas Kraus, Heyue Zhou, Yanliang Zhang, Namir Shaabani, Soner Yildiz, Na Du, Alok Singh, Lisa Miorin, Donghui Li, Karen Stegman, Sabrina Ophir, Xia Cao, Kristina Atanasoff, Reyna Lim, Ignacio Mena, Nicole M Bouvier, Shreyas Kowdle, Juan Manuel Carreño, Laura Rivero-Nava, Ariel Raskin, Elena Moreno, Sachi Johnson, Raveen Rathnasinghe, Chin I Pai, Thomas Kehrer, Elizabeth Paz Cabral, Sonia Jangra, Laura Healy, Gagandeep Singh, Prajakta Warang, Viviana Simon, Emilia Mia Sordillo, Harm van Bakel, Yonghong Liu, Weina Sun, Lisa Kerwin, John Teijaro, Michael Schotsaert, Florian Krammer, Damien Bresson, Adolfo García-Sastre, Yanwen Fu, Benhur Lee, Colin Powers, Thomas Moran, Henry Ji, Domenico Tortorella, Robert Allen
Journal: Med (N Y)
PubMed ID: 36044897
Doi: 10.1016/j.medj.2022.08.002
Products & Services: Mammalian Expression   
CAR-T Engager proteins optimize anti-CD19 CAR-T cell therapies for lymphoma
Authors: Lihe Su, Lan Wu, Roy R Lobb, Paul D Rennert, Christine Ambrose
Journal: Oncoimmunology
PubMed ID: 35990518
Doi: 10.1080/2162402X.2022.2111904
Products & Services: Mammalian Expression   
Novel antiinflammatory biologics shaped by parasite-host coevolution
Authors: Stephanie M Ryan, Roland Ruscher, Wayne A Johnston, Darren A Pickering, Malcolm W Kennedy, Brian O Smith, Linda Jones, Geraldine Buitrago, Matt A Field, Adrian J Esterman, Connor P McHugh, Daniel J Browne, Martha M Cooper, Rachael Y M Ryan, Denise L Doolan, Christian R Engwerda, Kim Miles, Makedonka Mitreva, John Croese, Tony Rahman, Kirill Alexandrov, Paul R Giacomin, Alex Loukas
Journal: Proc Natl Acad Sci U S A
PubMed ID: 36037362
Doi: 10.1073/pnas.2202795119
Products & Services: Mammalian Expression   
Structural basis for receptor selectivity and inverse agonism in S1P receptors
Authors: Elizaveta Lyapina, Egor Marin, Anastasiia Gusach, Philipp Orekhov, Andrey Gerasimov, Aleksandra Luginina, Daniil Vakhrameev, Margarita Ergasheva, Margarita Kovaleva, Georgii Khusainov, Polina Khorn, Mikhail Shevtsov, Kirill Kovalev, Sergey Bukhdruker, Ivan Okhrimenko, Petr Popov, Hao Hu, Uwe Weierstall, Wei Liu, Yunje Cho, Ivan Gushchin, Andrey Rogachev, Gleb Bourenkov, Sehan Park, Gisu Park, Hyo Jung Hyun, Jaehyun Park, Valentin Gordeliy, Valentin Borshchevskiy, Alexey Mishin, Vadim Cherezov
Journal: Nat Commun
PubMed ID: 35961984
Doi: 10.1038/s41467-022-32447-1
Products & Services: Mammalian Expression   
Golgin Subfamily A Member 5 Is Essential for Production of Extracellular Matrix Proteins during TGF-1-Induced Periodontal Ligament-Fibroblastic Differentiation
Authors: Hyun-Jin Kim, Seong-Min Kim, Min-Jeong Choi, Young-Joo Jang
Journal: Stem Cells Int
PubMed ID: 35879965
Doi: 10.1155/2022/3273779
Products & Services: Mammalian Expression   
PTPRO knockdown protects against inflammation in hemorrhage shock-induced lung injury involving the NF-κB signaling pathway
Authors: Zhirong Huan, Ying Tang, Ce Xu, Jimin Cai, Hao Yao, Yan Wang, Fanyu Bu, Xin Ge
Journal: Respir Res
PubMed ID: 35906634
Doi: 10.1186/s12931-022-02118-2
Products & Services: Mammalian Expression   
Impact of the temperature on the interactions between common variants of the SARS-CoV-2 receptor binding domain and the human ACE2
Authors: Catherine Forest-Nault, Izel Koyuturk, Jimmy Gaudreault, Alex Pelletier, Denis L'Abbé, Brian Cass, Louis Bisson, Alina Burlacu, Laurence Delafosse, Matthew Stuible, Olivier Henry, Gregory De Crescenzo, Yves Durocher
Journal: Sci Rep
PubMed ID: 35798770
Doi: 10.1038/s41598-022-15215-5
Products & Services: Mammalian Expression   

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