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FS145, the first flea-derived disintegrin, inhibits angiogenesis through specifically binding integrin αβ

Authors: Wancheng Lu, Zhijian Xiao, Hang Liao, Jianpeng Xie, Yihan Gao, Weichen Xiong, Qingye Zeng, Zhenhui Deng, Jiena Wu, Jinwei Chai, Xin Chen, Xueqing Xu

Journal: Int J Biol Macromol

PubMed ID: 38211910

Doi: 10.1016/j.ijbiomac.2024.129289

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Development of nanobodies specific to clumping factors A of Staphylococcus aureus by yeast surface display

Authors: Meng Mei, Mengqing Lu, Shiqi Li, Xinyi Ren, Banbin Xing, Yang Hu, Yuqi Wu, Huan Chen, Longhao Wang, Li Yi, Ke Ming, Zigong Wei

Journal: Int J Biol Macromol

PubMed ID: 38185298

Doi: 10.1016/j.ijbiomac.2024.129208

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Immunogenicity studies of recombinant RBD SARS-CoV-2 as a COVID-19 vaccine candidate produced in

Authors: Intan Aghniya Safitri, Yovin Sugijo, Fernita Puspasari, Fifi Fitriyah Masduki, Ernawati Arifin Giri-Rachman, Aluicia Anita Artarini, Marselina Irasonia Tan, Dessy Natalia

Journal: Vaccine X

PubMed ID: 38304876

Doi: 10.1016/j.jvacx.2024.100443

Products & Services: Molecular Biology Reagents

Genetic engineering employing MPB70 and its promoter enables efficient secretion and expression of foreign antigen in bacillus Calmette Guérin (BCG) Tokyo

Authors: Atsuki Takeishi, Amina K Shaban, Taichi Kakihana, Hayato Takihara, Shujiro Okuda, Hidekazu Osada, Desak Nyoman Surya Suameitria Dewi, Yuriko Ozeki, Yutaka Yoshida, Akihito Nishiyama, Yoshitaka Tateishi, Yuki Aizu, Yasushi Chuma, Kazuyo Onishi, Daisuke Hayashi, Saburo Yamamoto, Tetsu Mukai, Manabu Ato, Duong Huu Thai, Huynh Thi Thao Nhi, Tsuyoshi Shirai, Satoshi Shibata, Fumiko Obata, Jun Fujii, Seiya Yamayoshi, Maki Kiso, Sohkichi Matsumoto

Journal: Microbiol Immunol

PubMed ID: 38294180

Doi: 10.1111/1348-0421.13116

Products & Services: Molecular Biology Reagents

Studying the topology of peroxisomal acyl-CoA synthetases using self-assembling split sfGFP

Authors: Serhii Chornyi, Janet Koster, Lodewijk IJlst, Hans R Waterham

Journal: Histochem Cell Biol

PubMed ID: 38243092

Doi: 10.1007/s00418-023-02257-7

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Performance Analysis of Serodiagnostic Tests to Characterize the Incline and Decline of the Individual Humoral Immune Response in COVID-19 Patients: Impact on Diagnostic Management

Authors: Ronald von Possel, Babett Menge, Christina Deschermeier, Carlos Fritzsche, Christoph Hemmer, Hilte Geerdes-Fenge, Micha Loebermann, Anette Schulz, Erik Lattwein, Katja Steinhagen, Ralf Tönnies, Reiner Ahrendt, Petra Emmerich

Journal: Viruses

PubMed ID: 38257792

Doi: 10.3390/v16010091

Products & Services: Proteins, Expression, Isolation and Analysis

Generation and Application of Monoclonal Antibodies against Porcine S100A8, S100A9, and S100A12 Proteins Using Hybridoma Technology

Authors: Pengpeng Xia, Xin Ma, Li Yan, Siqi Lian, Xiangyu Li, Yi Luo, Ziyue Chen, Xingduo Ji

Journal: Int J Mol Sci

PubMed ID: 38256103

Doi: 10.3390/ijms25021029

Products & Services: Proteins, Expression, Isolation and Analysis

A Non-Functional Carbon Dioxide-Mediated Post-Translational Modification on Nucleoside Diphosphate Kinase of

Authors: Harry G Gannon, Amber Riaz-Bradley, Martin J Cann

Journal: Int J Mol Sci

PubMed ID: 38255974

Doi: 10.3390/ijms25020898

Products & Services: Proteins, Expression, Isolation and Analysis

Role of Histiocyte-Derived frHMGB1 as a Facilitator in Non-Canonical Pyroptosis of Monocytes/Macrophages in Lethal Sepsis

Authors: Yu Tian, Yuwen Cao, Fang Liu, Lin Xia, Chao Wang, Zhaoliang Su

Journal: J Infect Dis

PubMed ID: 38243905

Doi: 10.1093/infdis/jiae020

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Chimeric proteins of Mycoplasma hyopneumoniae as vaccine and preclinical model for immunological evaluation

Authors: Marcus Rebouças Santos, Leonardo Teófilo Toledo, Ênio José Bassi, Wagnner José Nascimento Porto, Gustavo Costa Bressan, Maria Aparecida S Moreira, Yung-Fu Chang, Abelardo Silva-Júnior

Journal: Braz J Microbiol

PubMed ID: 38217795

Doi: 10.1007/s42770-023-01240-7

Products & Services: Proteins, Expression, Isolation and Analysis

Electrically silent KvS subunits associate with native Kv2 channels in brain and impact diverse properties of channel function

Authors: Michael Ferns, Deborah van der List, Nicholas C Vierra, Taylor Lacey, Karl Murray, Michael Kirmiz, Robert G Stewart, Jon T Sack, James S Trimmer

Journal: biorxiv

PubMed ID: 38328147

Doi: 10.1101/2024.01.25.577135

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Recombinant T7 RNA polymerase production using ClearColi BL21(DE3) and animal-free media for in vitro transcription

Authors: Qianying Liang, Bowen Tu, Lun Cui

Journal: Appl Microbiol Biotechnol

PubMed ID: 38180552

Doi: 10.1007/s00253-023-12939-w

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Astragaloside IV regulates circ_0001615 and miR-873-5p/LASP1 axis to suppress colorectal cancer cell progression

Authors: Pengfei Kong, Xuemei Tang, Fang Liu, Xuegui Tang

Journal: Chem Biol Drug Des

PubMed ID: 38230773

Doi: 10.1111/cbdd.14423

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Prevalence of IgG antibodies against Malawi polyomavirus in patients with autoimmune diseases and lymphoproliferative disorders subjected to bone marrow transplantation

Authors: Jérôme T J Nicol, Elisa Mazzoni, Maria Rosa Iaquinta, Raffaella De Pace, Pauline Gaboriaud, Natalia Maximova, Carolina Cason, Eleonora De Martino, Chiara Mazziotta, Pierre Coursaget, Antoine Touzé, Valentina Boz, Manola Comar, Mauro Tognon, Fernanda Martini

Journal: Front Immunol

PubMed ID: 38299147

Doi: 10.3389/fimmu.2023.1293313

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Evolutionary preservation of CpG dinucleotides in RAG1 may elucidate the relatively high rate of methylation-mediated mutagenesis of RAG1 transposase

Authors: Mariam M Fawzy, Maiiada H Nazmy, Azza A K El-Sheikh, Moustafa Fathy

Journal: Immunol Res

PubMed ID: 38240953

Doi: 10.1007/s12026-023-09451-8

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Enhanced immunogenicity and protective efficacy in mice following a Zika DNA vaccine designed by modulation of membrane-anchoring regions and its association to adjuvants

Authors: Franciane Mouradian Emidio Teixeira, Luana de Mendonça Oliveira, Anna Cláudia Calvielli Castelo Branco, Ricardo Wesley Alberca, Emanuella Sarmento Alho de Sousa, Bruno Henrique de Sousa Leite, Wenny Camilla Dos Santos Adan, Alberto José da Silva Duarte, Roberto Dias Lins, Maria Notomi Sato, Isabelle Freire Tabosa Viana

Journal: Front Immunol

PubMed ID: 38361945

Doi: 10.3389/fimmu.2024.1307546

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A novel starch-active lytic polysaccharide monooxygenase discovered with bioinformatics screening and its application in textile desizing

Authors: Meijuan Zhang, Xiaoping Fu, Rongrong Gu, Bohua Zhao, Xingya Zhao, Hui Song, Hongchen Zheng, Jianyong Xu, Wenqin Bai

Journal: BMC Biotechnol

PubMed ID: 38200466

Doi: 10.1186/s12896-023-00826-1

Products & Services: Gene Synthesis

Inter-alpha-trypsin inhibitor (IαI) and hyaluronan modifications enhance the innate immune response to influenza virus in the lung

Authors: Fengying Tang, Stephen R Reeves, Jourdan E Brune, Mary Y Chang, Christina K Chan, Peter Waldron, Sheona P Drummond, Caroline M Milner, Kimberly M Alonge, Stavros Garantziotis, Anthony J Day, William A Altemeier, Charles W Frevert

Journal: Matrix Biol

PubMed ID: 38232913

Doi: 10.1016/j.matbio.2024.01.004

Products & Services: Proteins, Expression, Isolation and Analysis

Comparative immunogenicity and neutralizing antibody responses post heterologous vaccination with CoronaVac (Sinovac) and Vaxzevria (AstraZeneca) in HIV-infected patients with varying CD4+ T lymphocyte counts

Authors: Sorawit Chittrakarn, Pisud Siripaitoon, Sarunyou Chusri, Siripen Kanchanasuwan, Boonsri Charoenmak, Thanaporn Hortiwakul, Phaiwon Kantikit, Narongdet Kositpantawong

Journal: Hum Vaccin Immunother

PubMed ID: 38297904

Doi: 10.1080/21645515.2024.2309734

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Glycosylase-based base editors for efficient T-to-G and C-to-G editing in mammalian cells

Authors: Lijun Ye , Dongdong Zhao , Ju Li , Yiran Wang , Bo Li , Yuanzhao Yang , Xueting Hou , Huibin Wang , Zhandong Wei , Xiaoqi Liu , Yaqiu Li, Siwei Li , Yajing Liu , Xueli Zhang , Changhao Bi

Journal: Nat Biotechnol .

PubMed ID: 38168994

Doi: 10.1038/s41587-023-02050-w

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Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia

Authors: Wenhua Jiang, Qiangqiang Hou, Hongrui Xu, Kexin Yang, Xiaohui Wang, Kuojun Zhang, Yi Zeng, Wenqiang Li, Bingrui Wang, Guangmei Luo, Xiaofan Zhao, Hui Shen, Yong Xu, Xiaoxing Wu

Journal: J Med Chem

PubMed ID: 38175809

Doi: 10.1021/acs.jmedchem.3c02104

Products & Services: Proteins, Expression, Isolation and Analysis

Local Multiple-site Injections of a Plasmid Encoding Human Mitigate Radiation-induced Skin Injury by Inhibiting Ferroptosis

Authors: Xiaoying Wang, Yuxin Lu, Xiaochen Cheng, Xuefeng Zhu, Dujuan Li, Haiying Duan, Shenhui Hu, Fengjun Xiao, Li Du, Qinglin Zhang

Journal: Curr Drug Deliv

PubMed ID: 37157191

Doi: 10.2174/1567201820666230508120720

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Bioactive Polyurethane-Poly(ethylene Glycol) Diacrylate Hydrogels for Applications in Tissue Engineering

Authors: Yixuan Yuan, Caleb Tyson, Annika Szyniec, Samuel Agro, Tara N Tavakol, Alexander Harmon, DessaRae Lampkins, Lauran Pearson, Jerald E Dumas, Lakeshia J Taite

Journal: Gels

PubMed ID: 38391438

Doi: 10.3390/gels10020108

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Functionally coherent transcriptional responses of Jatropha curcas and Pseudomonas fragi for rhizosphere mediated degradation of pyrene

Authors: L Paikhomba Singha, K Malabika Singha, Piyush Pandey

Journal: Sci Rep

PubMed ID: 38200308

Doi: 10.1038/s41598-024-51581-y

Products & Services: PCR Cloning and Subcloning

A Mixture of T-Cell Epitope Peptides Derived from Human Respiratory Syncytial Virus F Protein Conferred Protection in DR1-TCR Tg Mice

Authors: Hong Guo, Yang Song, Hai Li, Hongqiao Hu, Yuqing Shi, Jie Jiang, Jinyuan Guo, Lei Cao, Naiying Mao, Yan Zhang

Journal: Vaccines (Basel)

PubMed ID: 38250890

Doi: 10.3390/vaccines12010077

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In situ vaccination via tissue-targeted cDC1 expansion enhances the immunogenicity of chemoradiation and immunotherapy

Authors: Brandon Lam, Yu Jui Kung, John Lin, Ssu-Hsueh Tseng, Hsin-Fang Tu, Claire Huang, Brandon Lee, Esteban Velarde, Ya Chea Tsai, Rafael Villasmil, Sung Taek Park, Deyin Xing, Chien-Fu Hung, T-C Wu

Journal: J Clin Invest

PubMed ID: 37917174

Doi: 10.1172/JCI171621

Products & Services: PCR Cloning and Subcloning

The naringenin-dependent regulator FdeR can be applied as a NIMPLY gate controlled by naringenin and arabinose

Authors: Fernanda Miyuki Kashiwagi, Brenno Wendler Miranda, Emanuel Maltempi de Souza, Marcelo Müller-Santos

Journal: Synth Biol (Oxf)

PubMed ID: 38249314

Doi: 10.1093/synbio/ysae001

Products & Services: Gene Synthesis

HCMV IE1/IE1mut Therapeutic Vaccine Induces Tumor Regression via Intratumoral Tertiary Lymphoid Structure Formation and Peripheral Immunity Activation in Glioblastoma Multiforme

Authors: Xiaoli Yang, Shasha Jiang, Fengjun Liu, Zonghui Li, Wenxuan Liu, Xianjuan Zhang, Fulong Nan, Jun Li, Meng Yu, Yunyang Wang, Bin Wang

Journal: Mol Neurobiol

PubMed ID: 38261253

Doi: 10.1007/s12035-024-03937-8

Products & Services: Recombinant Proteins

A Novel Role for the Adenovirus L4 Region 22K and 33K Proteins in Adeno-Associated Virus Production

Authors: Angela Adsero, Brendan Chestnut, Sara Shahnejat-Bushehri, Lalita Sasnoor, Travis McMurphy, Mike Swenor, Ryan Pasquino, Arun Pradhan, Victor Hernandez, Linas Padegimas, David Dismuke

Journal: Hum Gene Ther

PubMed ID: 38062776

Doi: 10.1089/hum.2023.146

Products & Services: Recombinant Proteins

Cascaded amplifying circuit enables sensitive detection of fungal pathogens

Authors: Cong Fan, Nike He, Jifeng Yuan

Journal: Biosens Bioelectron

PubMed ID: 38281368

Doi: 10.1016/j.bios.2024.116058

Products & Services: Gene Synthesis

An inducible CRISPRi circuit for tunable dynamic regulation of gene expression in Saccharopolyspora erythraea

Authors: Xing Jiang, Xiang Ke, Xiwei Tian, Ju Chu

Journal: Biotechnol Lett

PubMed ID: 38279045

Doi: 10.1007/s10529-023-03462-z

Products & Services: Gene Synthesis

Capsid protein mediated evasion of IRAK1-dependent signalling is essential to Sindbis virus neuroinvasion and virulence in mice

Authors: V Douglas Landers, Milton Thomas, Cierra M Isom, Deepa Karki, Kevin J Sokoloski

Journal: Emerg Microbes Infect

PubMed ID: 38164715

Doi: 10.1080/22221751.2023.2300452

Products & Services: Proteins, Expression, Isolation and Analysis

Estimation of the Parasitic Burden of Soil-Transmitted Helminths Among Pregnant Women in the Maharashtra State of India Using qPCR: A Community-Based Study

Authors: Shilpa Gaidhane, Abhay Gaidhane, Mahalaqua Nazli Khatib, Shital Telrandhe, Manoj Patil, Deepak Saxena, Pankaj Bhardwaj, Sonali Choudhari, Quazi S Zahiruddin

Journal: Indian J Community Med

PubMed ID: 38425985

Doi: 10.4103/ijcm.ijcm_249_23

Products & Services: PCR Cloning and Subcloning

Mitochondrial Homeostasis Regulating Mitochondrial Number and Morphology Is a Distinguishing Feature of Skeletal Muscle Fiber Types in Marine Teleosts

Authors: Busu Li, Huan Wang, Xianghui Zeng, Shufang Liu, Zhimeng Zhuang

Journal: Int J Mol Sci

PubMed ID: 38338790

Doi: 10.3390/ijms25031512

Products & Services: Proteins, Expression, Isolation and Analysis

Characterization of MdpS: an in-depth analysis of a MUC5B-degrading protease from

Authors: Fredrik Leo, Rolf Lood, Kristina A Thomsson, Jonas Nilsson, Gunnel Svensäter, Claes Wickström

Journal: Front Microbiol

PubMed ID: 38304711

Doi: 10.3389/fmicb.2024.1340109

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KDM6A Demethylase Regulates Renal Sodium Excretion and Blood Pressure

Authors: Xiaobin Han, Leah Akinseye, Zhongjie Sun

Journal: Hypertension

PubMed ID: 38164755

Doi: 10.1161/HYPERTENSIONAHA.123.22026

Products & Services: Proteins, Expression, Isolation and Analysis

Cyclic di-GMP inhibits nitrate assimilation by impairing the antitermination function of NasT in Pseudomonas putida

Authors: Liang Nie, Yujie Xiao, Tiantian Zhou, Haoqi Feng, Meina He, Qingyuan Liang, Kexin Mu, Hailing Nie, Qiaoyun Huang, Wenli Chen

Journal: Nucleic Acids Res

PubMed ID: 38000372

Doi: 10.1093/nar/gkad1117

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CGI1746 targets σ1R to modulate ferroptosis through mitochondria-associated membranes

Authors: Zili Zhang, Hong Zhou, Wenjia Gu, Yuehan Wei, Shan Mou, Youjun Wang, Jing Zhang & Qing Zhong

Journal: Nature Chemical Biology

PubMed ID: 38212578

Doi: 10.1038/s41589-023-01512-1

Products & Services: Recombinant Antibody Expression

Towards detection of structurally-diverse glycated epitopes in native proteins: Single-chain antibody directed to non-A1c epitope in human haemoglobin

Authors: Miss Lucia Gaetani, Isabel Campos Pinto, Meng Li, Peter O'Connor, Susan Giorgi-Coll, Matthew Tyreman, Katherine L Rumary, James A Schouten, Paul Davis, Ann M Dixon

Journal: Mol Immunol

PubMed ID: 38181455

Doi: 10.1016/j.molimm.2023.12.008

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A general platform for targeting MHC-II antigens via a single loop

Authors: Haotian Du, Jingjia Liu, Kevin M Jude, Xinbo Yang, Ying Li, Braxton Bell, Hongli Yang, Audrey Kassardjian, Ali Mobedi, Udit Parekh, R Andres Parra Sperberg, Jean-Philippe Julien, Elizabeth D Mellins, K Christopher Garcia, Po-Ssu Huang

Journal: biorxiv

PubMed ID: 38352315

Doi: 10.1101/2024.01.26.577489

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PRMT3 methylates HIF-1α to enhance the vascular calcification induced by chronic kidney disease

Authors: Guangyu Zhou, Chen Zhang, Hui Peng, Xuesong Su, Qun Huang, Zixia Zhao, Guangyi Zhao

Journal: Mol Med

PubMed ID: 38200452

Doi: 10.1186/s10020-023-00759-7

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Structural biases in disordered proteins are prevalent in the cell

Authors: David Moses, Karina Guadalupe, Feng Yu, Eduardo Flores, Anthony R Perez, Ralph McAnelly, Nora M Shamoon, Gagandeep Kaur, Estefania Cuevas-Zepeda, Andrea D Merg, Erik W Martin, Alex S Holehouse, Shahar Sukenik

Journal: Nat Struct Mol Biol

PubMed ID: 38177684

Doi: 10.1038/s41594-023-01148-8

Products & Services: Gene Synthesis

Response to COVID-19 vaccination in patients on cancer therapy: Analysis in a SARS-CoV-2-naïve population

Authors: George Cavic, Andrew A Almonte, Sarah M Hicks, Teresa Neeman, Jo-Wai Wang, Sue Brew, Philip Y Choi, Ian Cockburn, Elizabeth E Gardiner, Desmond Yip, Aude M Fahrer, Yada Kanjanapan

Journal: Asia Pac J Clin Oncol

PubMed ID: 38221764

Doi: 10.1111/ajco.14047

Products & Services: Recombinant Proteins

PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial

Authors: Francisco J Martinez, Michael White, Micheline Guillotte-Blisnick, Christèle Huon, Alix Boucharlat, Fabrice Agou, Patrick England, Jean Popovici, Mimi M Hou, Sarah E Silk, Jordan R Barrett, Carolyn M Nielsen, Jenny M Reimer, Paushali Mukherjee, Virander S Chauhan, Angela M Minassian, Simon J Draper, Chetan E Chitnis

Journal: npj Vaccines

PubMed ID: 38184681

Doi: 10.1038/s41541-023-00796-7

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PARP trapping is governed by the PARP inhibitor dissociation rate constant

Authors: Angelica A Gopal, Bianca Fernandez, Justin Delano, Ralph Weissleder, J Matthew Dubach

Journal: Cell Chem Biol

PubMed ID: 38262416

Doi: 10.1016/j.chembiol.2023.12.019

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Exploring a novel long-acting glucagon-like peptide-1 receptor agonist built on the albumin-binding domain and XTEN scaffolds

Authors: Yan Zhou, Jianhui Li, Guosheng Gao, Yafeng Li, Changzhen Zhang

Journal: Heliyon

PubMed ID: 38293540

Doi: 10.1016/j.heliyon.2024.e24340

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Comparative Study on the Immunogenicity of COVID-19 mRNA Vaccines in Patients Receiving Adjuvant and Palliative Chemotherapy

Authors: Hyun-Woo Choi, Younggon Jung, Uh Jin Kim, Sang-Cheol Lee, Jung Hye Kwon, Hyeonjong Kim, Sarah Kim, Yoonjung Lee, Hyun-Jung Shim, Sang-Hee Cho, Ik-Joo Chung, Eu Chang Hwang, Seung Ji Kang, Woo Kyun Bae, Seung-Jung Kee

Journal: Chonnam Med J

PubMed ID: 38304127

Doi: 10.4068/cmj.2024.60.1.69

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Improving and Streamlining Gene Editing in via Integration of Engineered Cas9 Protein

Authors: Baixi Zhang, Jiacan Cao

Journal: J Fungi (Basel)

PubMed ID: 38248972

Doi: 10.3390/jof10010063

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A metalloprotein nanoparticle scaffold co-delivers antigens and adjuvants with metal-enhanced STING activation for vaccination preventing viral infections

Authors: Jiexin Li , Qian Qiu , He Ren , Jingyu Zhang , Chen Zhang , Gengqi Liu , Boyang Sun , Bin Zheng , Jonathan F. Lovell , Yumiao Zhang