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Conservation of Affinity Rather Than Sequence Underlies a Dynamic Evolution of the Motif-Mediated p53/MDM2 Interaction in Ray-Finned Fishes
Authors: Filip Mihalič, Dahiana Arcila, Mats E Pettersson, Pouria Farkhondehkish, Eva Andersson, Leif Andersson, Ricardo Betancur-R, Per Jemth
Journal: Mol Biol Evol
PubMed ID: 38301272
Doi: 10.1093/molbev/msae018
Tandem repeats of highly bioluminescent NanoLuc are refolded noncanonically by the Hsp70 machinery
Authors: Dimitra Apostolidou, Pan Zhang, Devanshi Pandya, Kaden Bock, Qinglian Liu, Weitao Yang, Piotr E Marszalek
Journal: Protein Sci
PubMed ID: 38284490
Doi: 10.1002/pro.4895
Products & Services: Custom Vector Construction   
Chagasin from Trypanosoma cruzi as a molecular scaffold to express epitopes of TSA-1 as soluble recombinant chimeras
Authors: Rosa Elena Cárdenas-Guerra, Octavio Montes-Flores, Edgar Ezequiel Nava-Pintor, Gerardo Reséndiz-Cardiel, Claudia Ivonne Flores-Pucheta, Yasmín Irene Rodríguez-Gavaldón, Rossana Arroyo, Maria Elena Bottazzi, Peter J Hotez, Jaime Ortega-López
Journal: Protein Expr Purif
PubMed ID: 38423156
Doi: 10.1016/j.pep.2024.106458
Products & Services: Codon Optimization   
Systematic Engineering of for Efficient Production of Cytidine 5'-Monophosphate
Authors: Min Zhou, Liyuan Wei, Chongzhi Wu, Wei Chen, Zhengju Tang
Journal: ACS Omega
PubMed ID: 38371780
Doi: 10.1021/acsomega.3c07713
Products & Services: Custom DNA/RNA Oligos   
Supramolecular Synthons in Protein-Ligand Frameworks
Authors: Ronan J Flood, Niamh M Mockler, Aurélien Thureau, Maura Malinska, Peter B Crowley
Journal: Cryst Growth Des
PubMed ID: 38463617
Doi: 10.1021/acs.cgd.3c01480
Products & Services: Molecular Biology Reagents   
Antibodies toward Na,HCO-cotransporter NBCn1/SLC4A7 block net acid extrusion and cause pH-dependent growth inhibition and apoptosis in breast cancer
Authors: Trine V Axelsen, Claus Olesen, Danish Khan, Ali Mohammadi, Elena V Bouzinova, Christine J F Nielsen, Marco Mele, Katrine R Hauerslev, Helene L Pedersen, Eva Balling, Pernille Vahl, Trine Tramm, Peer M Christiansen, Ebbe Boedtkjer
Journal: Br J Cancer
PubMed ID: 38310186
Doi: 10.1038/s41416-024-02591-0
Products & Services: Catalog Antibody   
A mutational atlas for Parkin proteostasis
Authors: Lene Clausen, Vasileios Voutsinos, Matteo Cagiada, Kristoffer E Johansson, Martin Grønbæk-Thygesen, Snehal Nariya, Rachel L Powell, Magnus K N Have, Vibe H Oestergaard, Amelie Stein, Douglas M Fowler, Kresten Lindorff-Larsen, Rasmus Hartmann-Petersen
Journal: Nat Commun
PubMed ID: 38378758
Doi: 10.1038/s41467-024-45829-4
Products & Services: Mutagenesis Services   
Constitutive activation mechanism of a class C GPCR
Authors: Jinwoo Shin, Junhyeon Park, Jieun Jeong, Jordy Homing Lam, Xingyu Qiu, Di Wu, Kuglae Kim, Joo-Youn Lee, Carol V Robinson, Jaekyung Hyun, Vsevolod Katritch, Kwang Pyo Kim, Yunje Cho
Journal: Nat Struct Mol Biol
PubMed ID: 38332368
Doi: 10.1038/s41594-024-01224-7
Design, quality and validation of the EU-OPENSCREEN fragment library poised to a high-throughput screening collection
Authors: Xavier Jalencas, Hannes Berg, Ludvik Olai Espeland, Sridhar Sreeramulu, Franziska Kinnen, Christian Richter, Charis Georgiou, Vladyslav Yadrykhinsky, Edgar Specker, Kristaps Jaudzems, Tanja Miletić, Robert Harmel, Phil Gribbon, Harald Schwalbe, Ruth Brenk, Aigars Jirgensons, Andrea Zaliani, Jordi Mestres
Journal: RSC Med Chem
PubMed ID: 38665834
Doi: 10.1039/d3md00724c
Cystatin from the helminth upregulates mevalonate and cholesterol biosynthesis pathways and immunomodulatory genes in human monocyte-derived dendritic cells
Authors: Nathalie Acevedo, Ana Lozano, Josefina Zakzuk, Kevin Llinás-Caballero, David Brodin, Peter Nejsum, Andrew R Williams, Luis Caraballo
Journal: Front Immunol
PubMed ID: 38481989
Doi: 10.3389/fimmu.2024.1328401
Products & Services: Molecular Biology Reagents   

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