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Development of a highly sensitive C1QC-targeting aptamer and its application in a modified antibody-aptamer sandwich biosensor for C1QC biomarker detection

Authors: Wenwei Wu, Lixia Qian, Jie Shen, Hongmei Li, Liang-cheng Li

Journal: Sensors and Actuators: B. Chemical

Doi: doi.org/10.1016/j.snb.2025.137828

Products & Services: CRISPR KI Templates

Developmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition

Authors: Meihui Tao, Li Wang, Chaoyue Chen, Mengfan Tang, Yanping Wang, Jingyue Zhang, Xi Zhao, Qinyu Feng, Junfa Chen, Wei Yan, Rong Lin, Yu Fu

Journal: Journal of Advanced Research

PubMed ID: 40288675

Doi: 10.1016/j.jare.2025.04.030

Products & Services: Mammalian Expression Recombinant Proteins

An evolutionarily unique viral RdRP suggests a common dual-function feature of the priming element

Authors: Hengxia Jia, Shunli Liu, Guibo Rao, Qiaojie Liu, Jiqin Wu, Sheng Cao, Peng Gong

Journal: Sci Adv

PubMed ID: 40249801

Doi: 10.1126/sciadv.adv9640

Products & Services: Gene Synthesis Custom Vector Construction

Fused exosomal targeted therapy in periprosthetic osteolysis through regulation of bone metabolic homeostasis

Authors: Tianliang Ma, Qimeng Liu, Zheyu Zhang, Jiangyu Nan, Guanzhi Liu, Yute Yang, Yihe Hu, Jie Xie

Journal: Bioactive Materials

PubMed ID: 40248188

Doi: doi.org/10.1016/j.bioactmat.2025.04.006

Products & Services: Protein and Antibody Isolation

Identification of RC3H1 as antiviral host factor binding to the non-structural protein 1 of Influenza A virus via a 3-stage computational pipeline and cell-based analysis

Authors: Swee Teng Teo , Shamima Rashid , Kong Yen Liew , Kah Man Lai , Teng Ann Ng , Jifeng Jiao , Chee Keong Kwoh , Yee-Joo Tan

Journal: Virology Journal

PubMed ID: 40287742

Doi: 10.1186/s12985-025-02746-2

Products & Services: ORF cDNA Clones/MolecularCloud

Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment

Authors: Zhuoyao Chen, Gamma Chi, Timea Balo, Xiangrong Chen, Beatriz Ralsi Montes, Steven C. Clifford, Vincenzo D’Angiolella, Timea Szabo, Arpad Kiss, Tibor Novak, András Herner, András Kotschy & Alex N. Bullock

Journal: Nature Communications

PubMed ID: 40175372

Doi: 10.1038/s41467-025-58350-z

Products & Services: Gene Synthesis

Enhanced the Trans-Cleavage Activity of CRISPR-Cas12a Using Metal-Organic Frameworks as Stimulants for Efficient Electrochemical Sensing of Circulating Tumor DNA

Authors: Shuai Wu, Yincheng Liu, Tianyu Zeng, Tianci Zhou, Yanting Sun, Ying Deng, Juan Zhang, Genxi Li, Yongmei Yin

Journal: Advanced Science

PubMed ID: 40184611

Doi: 10.1002/advs.202417206

Products & Services: Gene Synthesis

Chromosome end protection by RAP1-mediated inhibition of DNA-PK

Authors: Patrik Eickhoff, Ceylan Sonmez, Charlotte E. L. Fisher, Oviya Inian, Theodoros I. Roumeliotis, Angela dello Stritto, Jörg Mansfeld, Jyoti S. Choudhary, Sebastian Guettler, Francisca Lottersberger & Max E. Douglas

Journal: Nature

PubMed ID: 40240611

Doi: 10.1038/s41586-025-08896-1

Products & Services: Gene Synthesis

Stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids

Authors: Jennifer M. Podgorski, Joshua Podgorski, Lawrence Abad, Deborah Jacobs-Sera, Krista G. Freeman, Colin Brown, Graham F. Hatfull, Antoni Luque & Simon J. White

Journal: Nature Communications

PubMed ID: 40175362

Doi: 10.1038/s41467-025-58298-0

Products & Services: Gene Synthesis

CD22 TCR-engineered T cells exert antileukemia cytotoxicity without causing inflammatory responses

Authors: Kilyna A Nguyen, Zhihui Liu, John S Davies, Crystal P McIntosh, Lindsey M Draper, Scott M Norberg, Zachary Rae, Sooraj R Achar, Gregoire Altan-Bonnet, Ling Zhang, Xiaolin Wu, Thomas J Meyer, Michael C Kelly, Naomi Taylor, Christian S Hinrichs, Kazusa Ishii

Journal: SCIENCE ADVANCES

PubMed ID: 40203088

Doi: 10.1126/sciadv.adq4297

Products & Services: Gene Synthesis