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A basigin antibody modulates MCTs to impact tumor metabolism and immunity
Authors: Heng Zhang, Xuemei Yang, Yue Xue, Yi Huang, Yingxi Mo, Yurun Huang, Hong Zhang, Xiaofei Zhang, Weixin Zhao, Bin Jia, Ningning Li, Ning Gao, Yue Yang, Dongxi Xiang, Shan Wang, Yi Qin Gao, Jun Liao
Journal: Cell Discovery
PubMed ID: 40324980
Doi: 10.1038/s41421-025-00777-1
Products & Services: Protein and Antibody Isolation   
Inhibiting peptidylarginine deiminases (PAD1-4) by targeting a Ca2+ dependent allosteric binding site
Authors: Leslie A Dakin, Li Xing, Justin Hall, Weidong Ding, Felix F Vajdos, Jeffrey W Pelker, Simeon Ramsey, Paul Balbo, Parag V Sahasrabudhe, Mary Ellen Banker, Won Young Choi, Stephen W Wright, Jeanne S Chang, John M Curto, Jennifer E Davoren, Susan E Drozda, Kimberly F Fennell, Kentaro Futatsugi, Steve Kortum, Katherine L Lee, Shenping Liu, Frank Lovering, Jennifer A Nicki, John I Trujillo, Fabien Vincent, Mark E Schnute
Journal: Nature Communications
PubMed ID: 40379660
Doi: 10.1038/s41467-025-59919-4
Products & Services: Gene Synthesis   
Interaction networks of SIM-binding groove mutants reveal alternate modes of SUMO binding and profound impact on SUMO conjugation
Authors: Laura A Claessens, Matty Verlaan-de Vries, Nienke Broekman, Martijn S Luijsterburg, Alfred C O Vertegaal
Journal: SCIENCE ADVANCES
PubMed ID: 40367183
Doi: 10.1126/sciadv.adp2643
Products & Services: Gene Synthesis   
A FAN1 point mutation associated with accelerated Huntington's disease progression alters its PCNA-mediated assembly on DNA
Authors: Jonas Aretz, Gayathri Jeyasankar, Anna Salerno-Kochan, Maren Thomsen, Gabriel Thieulin-Pardo, Tasir Haque, Edith Monteagudo, Dan Felsenfeld, Michael Finley, Thomas F Vogt, Julien Boudet, Brinda C Prasad
Journal: Nature Communications
PubMed ID: 40368883
Doi: 10.1038/s41467-025-59324-x
Products & Services: Gene Synthesis   
Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3
Authors: Qishun Zhou, Theo Sagmeister, Saskia Hutten, Benjamin Bourgeois, Tea Pavkov-Keller, Dorothee Dormann, Tobias Madl
Journal: Nature Communications
PubMed ID: 40360518
Doi: 10.1038/s41467-025-59802-2
Products & Services: Custom Vector Construction   
Microglial MS4A4A Protects against Epileptic Seizures in Alzheimer's Disease
Authors: Meng Jiang, Qingqing Li, Jianhui Chen, Ruochong Li, Jun Yao, Yong Hu, Haizheng Zhang, Lixin Cai, Maoguo Luo, Yu Sun, Wenwen Zeng
Journal: Advanced Science
PubMed ID: 40349168
Doi: 10.1002/advs.202417733
Products & Services: Protein and Antibody Isolation   
Cell trajectory modulation: rapid microfluidic biophysical profiling of CAR T cell functional phenotypes
Authors: Kerwin Kwek Zeming, Kai Yun Quek, Wei-Xiang Sin, Denise Bei Lin Teo, Ka-Wai Cheung, Chin Ren Goh, Faris Kairi, Elizabeth Lee, Francesca Lorraine Wei Inng Lim, Michaela Su-Fern Seng, Shui Yen Soh, Michael E Birnbaum, Jongyoon Han
Journal: Nature Communications
PubMed ID: 40404664
Doi: 10.1038/s41467-025-59789-w
Products & Services: Plasmid DNA Preparation   
LLPS REDIFINE allows the biophysical characterization of multicomponent condensates without tags or labels
Authors: Mihajlo Novakovic, Yaning Han, Nina C Kathe, Yinan Ni, Leonidas Emmanouilidis, Frédéric H-T Allain
Journal: Nature Communications
PubMed ID: 40389460
Doi: 10.1038/s41467-025-59759-2
Products & Services: Custom Vector Construction   
Human mitochondrial ferritin exhibits highly unusual iron-O2 chemistry distinct from that of cytosolic ferritins
Authors: Justin M Bradley , Zinnia Bugg , Jacob Pullin , Geoffrey R Moore, Dimitri A Svistunenko , Nick E Le Brun
Journal: Nature Communications
PubMed ID: 40393986
Doi: 10.1038/s41467-025-59463-1
Products & Services: Mutagenesis Services   
HR eye & MMR eye: one-day assessment of DNA repair-defective tumors eligible for targeted therapy
Authors: Shinta Saito, Shingo Kato, Usaki Arai, Atsuki En, Jun Tsunezumi, Taichi Mizushima, Kensuke Tateishi, Noritaka Adachi
Journal: Nature Communications
PubMed ID: 40355434
Doi: 10.1038/s41467-025-59462-2
Products & Services: Gene Synthesis   
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