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Efficient gene knockout and genetic interaction screening using the in4mer CRISPR/Cas12a multiplex knockout platform
Authors: Nazanin Esmaeili Anvar, Chenchu Lin, Xingdi Ma, Lori L Wilson, Ryan Steger, Annabel K Sangree, Medina Colic, Sidney H Wang, John G Doench, Traver Hart
Journal: Nat Commun
PubMed ID: 38678031
Doi: 10.1038/s41467-024-47795-3
Products & Services: Gene Synthesis   
A folate inhibitor exploits metabolic differences in Pseudomonas aeruginosa for narrow-spectrum targeting
Authors: Connor Chain, Joseph P Sheehan, Xincheng Xu, Soodabeh Ghaffari, Aneesh Godbole, Hahn Kim, Joel S Freundlich, Joshua D Rabinowitz, Zemer Gitai
Journal: Nature Microbiology
PubMed ID: 38594311
Doi: 10.1038/s41564-024-01665-2
Products & Services: Antibody Modification and Purification Services   
Antisense oligonucleotide therapeutic approach for Timothy syndrome
Authors: Xiaoyu Chen, Fikri Birey,John Huguenard, Sergiu P Pașca
Journal: Nature
PubMed ID: 38658687
Doi: 10.1038/s41586-024-07310-6
Structural basis for human Cav3.2 inhibition by selective antagonists
Authors: Jian Huang, Xiao Fan, Xueqin Jin, Chen Lyu, Qinmeng Guo, Tao Liu, Jiaofeng Chen, Amaël Davakan, Philippe Lory, Nieng Yan
Journal: Cell Research
PubMed ID: 38605177
Doi: 10.1038/s41422-024-00959-8
Products & Services: Peptide Synthesis   
Comparison of antibody-based immunotherapeutics for malignant hematological disease in an experimental murine model
Authors: Karin Frebel, Jörn C Albring, Anika Wohlgemuth, Christian Schwöppe, Stephan Hailfinger, Georg Lenz, Matthias Stelljes
Journal: Blood
PubMed ID: 38197968
Doi: 10.1182/bloodadvances.2023011647
Products & Services: Molecular Biology Reagents   
Somatic and intergenerational G4C2 hexanucleotide repeat instability in a human C9orf72 knock-in mouse model
Authors: Nada Kojak, Junko Kuno, Kristina E Fittipaldi, Ambereen Khan, David Wenger, Michael Glasser, Roberto A Donnianni, Yajun Tang, Jade Zhang, Katie Huling, Roxanne Ally, Alejandro O Mujica, Terrence Turner, Gina Magardino, Pei Yi Huang, Sze Yen Kerk, Gustavo Droguett, Marine Prissette, Jose Rojas, Teodoro Gomez, Anthony Gagliardi, Charleen Hunt, Jeremy S Rabinowitz, Guochun Gong, William Poueymirou, Eric Chiao, Brian Zambrowicz, Chia-Jen Siao, Daisuke Kajimura
Journal: Nucleic Acids Res
PubMed ID: 38597682
Doi: 10.1093/nar/gkae250
Products & Services: PCR Cloning and Subcloning   
A hemoprotein with a zinc-mirror heme site ties heme availability to carbon metabolism in cyanobacteria
Authors: Nicolas Grosjean, Estella F Yee, Desigan Kumaran, Kriti Chopra, Macon Abernathy, Sandeep Biswas, James Byrnes, Dale F Kreitler, Jan-Fang Cheng, Agnidipta Ghosh, Steven C Almo, Masakazu Iwai, Krishna K Niyogi, Himadri B Pakrasi, Ritimukta Sarangi, Hubertus van Dam, Lin Yang, Ian K Blaby, Crysten E Blaby-Haas
Journal: Nature Communications
PubMed ID: 38609367
Doi: 10.1038/s41467-024-47486-z
Products & Services: Proteins, Expression, Isolation and Analysis   
Human inherited PD-L1 deficiency is clinically and immunologically less severe than PD-1 deficiency
Authors: Matthew B Johnson, Masato Ogishi, Clara Domingo-Vila, Elisa De Franco, Matthew N Wakeling, Zineb Imane, Brittany Resnick, Evangelia Williams, Rui Pedro Galão, Richard Caswell, James Russ-Silsby, Yoann Seeleuthner , Darawan Rinchai, Iris Fagniez, Basilin Benson, Matthew J Dufort, Cate Speake , Megan E Smithmyer, Michelle Hudson, Rebecca Dobbs; EXE-T1D consortium; Zoe Quandt, Andrew T Hattersley ,Peng Zhang, Stephanie Boisson-Dupuis , Mark S Anderson, Jean-Laurent Casanova, Timothy I Tree, Richard A Oram
Journal: Journal Of Experimental Medicine
PubMed ID: 38634869
Doi: 10.1084/jem.20231704
Products & Services: Catalog Antibody   
Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade
Authors: Hao Nie, Pratima Saini, Taito Miyamoto, Liping Liao, Rafal J Zielinski, Heng Liu, Wei Zhou, Chen Wang, Brennah Murphy, Martina Towers, Tyler Yang, Yuan Qi, Toshitha Kannan, Andrew Kossenkov, Hiroaki Tateno, Daniel T Claiborne, Nan Zhang, Mohamed Abdel-Mohsen, Rugang Zhang
Journal: Nature Communications
PubMed ID: 38565883
Doi: 10.1038/s41467-024-47069-y
Products & Services: Gene Synthesis   
Ferroptosis and HMGB2 induced calreticulin translocation required for immunogenic cell death are controlled by the nuclear exporter XPO1
Authors: Ian Blair, Jingqi Fan, Kevin Gillespie, Clementina Mesaros
Journal: Res Sq
PubMed ID: 38496553
Doi: 10.21203/rs.3.rs-4009459/v1
Products & Services: Molecular Biology Reagents   

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