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Ligands Exert Biased Activity to Regulate Sigma 1 Receptor Interactions With Cationic TRPA1, TRPV1, and TRPM8 Channels.

Authors: Cortés-Montero E, Sánchez-Blázquez P, Onetti Y, Merlos M, Garzón J.

Journal: Front Pharmacol

PubMed ID: 31249525

Doi: 10.3389/fphar.2019.00634

Products & Services: Gene Synthesis

Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor.

Authors: Rodríguez-Muñoz M, Onetti Y, Cortés-Montero E, Garzón J, Sánchez-Blázquez P.

Journal: Mol Brain

PubMed ID: 30223868

Doi: 10.1186/s13041-018-0395-2

Products & Services: Recombinant Proteins

The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control.

Authors: Rodriguez-Munoz M, Sanchez-Blazquez P, Herrero-Labrador R, Martinez-Murillo R, Merlos M, Vela JM, GarzÓn J.

Journal: Antioxid Redox Signal. 22(10):799-818

PubMed ID: 25557043

Products & Services: Recombinant Proteins

The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.

Authors: Rodríguez-Muñoz M, Cortés-Montero E, Pozo-Rodrigálvarez A, Sánchez-Blázquez P, Garzón-Niño J.

Journal: Oncotarget

PubMed ID: 26461475

Doi: 10.18632/oncotarget.6064

Products & Services: Biochemicals

Cannabinoid receptors couple to NMDA receptors to reduce the production of NO and the mobilization of zinc induced by glutamate.

Authors: SÁnchez-BlÁzquez P, RodrÍguez-Muñoz M, Vicente-SÁnchez A, GarzÓn J.

Journal: Antioxid Redox Signal.

PubMed ID: 23600761

Products & Services: Biochemicals

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