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Zebrafish Lbh-like Is Required for Otx2-mediated Photoreceptor Differentiation.

Int J Biol Sci.. 2015-11; 
Wen-Hua Li, Li Zhou, Zhi Li, Yang Wang, Jian-Tao Shi, Yan-Jing Yang, Jian-Fang Gui. Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, Hubei, China.
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摘要

The homeobox transcription factor orthodenticle homolog 2 (otx2) is supposed as an organizer that orchestrates a transcription factor network during photoreceptor development. However, its regulation in the process remains unclear. In this study, we have identified a zebrafish limb bud and heart-like gene (lbh-like), which is expressed initially at 30 hours post fertilization (hpf) in the developing brain and eyes. Lbh-like knockdown by morpholinos specifically inhibits expression of multiple photoreceptor-specific genes, such as opsins, gnat1, gnat2 and irbp. Interestingly, otx2 expression in the morphants is not significantly reduced until 32 hpf when lbh-like begins to express, but its expression level in 72... More

关键词

Lbh-like; retina development; photoreceptor differentiation; otx2; Notch