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Structure activity relationship modelling of milk protein-derived peptides with dipeptidyl peptidase IV (DPP-IV) inhibitory activity.

Peptides.. 2016-05; 
Nongonierma AB, FitzGerald RJ.
Products/Services Used Details Operation
Catalog Products ... the QSAR model, ie, FP, HP, RP, VP, IPM, LPP, IPPL and IPSK, were obtained from Thermo Fisher Scientific (Ulm, Germany) while VPGEIVE, YPFPGP, LPQNIPPLT, IPPLTQT, TPVVVPP, YPVEPF, LPLPLL, QPHQPLPPT, QPLPPT, LPVPQ were from Genscript (Piscataway, NJ ... Get A Quote

摘要

Quantitative structure activity type models were developed in an attempt to predict the key features of peptide sequences having dipeptidyl peptidase IV (DPP-IV) inhibitory activity. The models were then employed to help predict the potential of peptides, which are currently reported in the literature to be present in the intestinal tract of humans following milk/dairy product ingestion, to act as inhibitors of DPP-IV. Two models (z- and v-scale) for short (2-5 amino acid residues) bovine milk peptides, behaving as competitive inhibitors of DPP-IV, were developed. The z- and the v-scale models (p<0.05, R(2) of 0.829 and 0.815, respectively) were then applied to 56 milk protein-derived peptides previously report... More

关键词

Bioactive peptides; Dipeptidyl peptidase IV inhibition; Milk proteins; Structure activity modelling