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Gamma-Aminobutyric acidergic projections from the dorsal raphe to the nucleus accumbens are regulated by neuromedin U.

Biol Psychiatry.. 2016-10; 
Kasper JM, McCue DL, Milton AJ, Szwed A, Sampson CM, Huang M, Carlton S, Meltzer HY, Cunningham KA, Hommel JD.
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Catalog Products ... Rats were habituated to being held by hand and microinjections of aCSF or 0.3 nmol NMU (porcine 8-mer sequence, GenScript, Township, NJ) in aCSF were administered at 1 µl per minute for 2 minutes. Sensitized locomotor activity. ... Get A Quote

摘要

BACKGROUND:Neuromedin U (NMU) is a neuropeptide enriched in the nucleus accumbens shell (NAcSh), a brain region associated with reward. While NMU and its receptor, NMU receptor 2 (NMUR2), have been studied for the ability to regulate food reward, NMU has not been studied in the context of drugs of abuse (e.g., cocaine). Furthermore, the neuroanatomical pathways that express NMUR2 and its ultrastructural localization are unknown. METHODS:Immunohistochemistry was used to determine the synaptic localization of NMUR2 in the NAcSh and characterize which neurons express this receptor (n = 17). The functional outcome of NMU on NMUR2 was examined using microdialysis (n = 16). The behavioral effects of NMU microinjectio... More

关键词

AAV6; Cocaine; GABA; Neuropeptide; Nonserotonergic; RNAi