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Identification of possible siRNA Molecules for TDP43 Mutants causing Amyotrophic Lateral Sclerosis: in silico design and molecular dynamics study.

Comput Biol Chem.. 2016-04; 
Bhandare VV, Ramaswamy A.
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Molecular Biology Tools ... Herpes simplex virus (HSV), which infects higher mammals does not have an effective treatment yet. Nur et al. have designed potent siRNAs using multiple tools like siDirect, Dharmacon design centre genscript, etc. to successfully target this HSV (Nur et al., 2013). ... Get A Quote

摘要

The DNA binding protein, TDP43 is a major protein involved in amyotrophic lateral sclerosis and other neurological disorders such as frontotemporal dementia, Alzheimer disease, etc. In the present study, we have designed possible siRNAs for the glycine rich region of tardbp mutants causing ALS disorder based on a systematic theoretical approach including (i) identification of respective codons for all mutants (reported at the protein level) based on both minimum free energy and probabilistic approaches, (ii) rational design of siRNA, (iii) secondary structure analysis for the target accessibility of siRNA, (iii) determination of the ability of siRNA to interact with mRNA and the formation/stability of duplex vi... More

关键词

Amyotrophic lateral sclerosis; Molecular dynamics simulation; RNAi; siRNA; tdp43