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Bone healing in rabbit calvarial critical-sized defects filled with stem cells and growth factors combined with granular or solid scaffolds.

Childs Nerv Syst.. 2016-04; 
Lappalainen OP, Karhula S, Haapea M, Kyllönen L, Haimi S, Miettinen S, Saarakkala S, Korpi J, Ylikontiola LP, Serlo WS, Sándor GK.
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Catalog Products ... After sterilization, the BAG scaffolds were incubated at +37 °C with control medium or medium supplemented with 50 ng/ml of recombinant hu- man BMP-2 (rhBMP-2; Genscript, NJ, USA), 100 ng/ml of BMP-7 (rhBMP-7; Sigma Aldrich, MO, USA), or 20 ng/ml of VEGF-A ... Get A Quote

摘要

PURPOSE: In pediatric neurosurgery, decompressive craniectomy and correction of congenital cranial anomalies can result in major cranial defects. Corrective cranioplasty for the repair of these critical-sized defects is not only a cosmetic issue. The limited availability of suitable autogenous bone and the morbidity of donor site harvesting have driven the search for new approaches with biodegradable and bioactive materials. This study aimed to assess the healing of rabbit calvarial critical-sized defects filled with osteogenic material, either with bioactive glass scaffolds or tricalcium phosphate granules in various combinations with adipose stem cells or bone marrow stem cells, BMP-2, BMP-7, or VEGF to enha... More

关键词

Bone healing; Cranial defect; Micro-CT; Stem cells