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Multi-walled carbon nanotubes enhanced fungal colonization and suppressed innate immune response to fungal infection in nematodes.

Toxicol. Res.. 2016-05; 
Shumaila Shakoor;Lingmei Sun;Dayong Wang.
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Monoclonal Antibody Services ... anti-Actin monoclonal antibody MAB1501 (1:5,000) was from EMD Millipore. Goat 140 anti-mouse IgG antibody (H&L) [HRP] (1:10,000) was from GenScript. Nematode protein 141 extracts were electrophoresed on a 10% sodium dodecyl sulfate-polyacrylamide gel 142 ... Get A Quote

摘要

The underlying molecular mechanisms for multi-walled carbon nanotube (MWCNT)-induced in vivo toxicity on innate immunity are still largely unclear. Considering the potential of Caenorhabditis elegans for the study of innate immune response of animals, we employed this in vivo assay system to investigate the e ff ects of MWCNTs on innate immune response of animals and the underlying mechanisms. Pre- exposure to MWCNTs at concentrations more than 100 μ gL − 1 enhanced the adverse e ff ect of fungal infection in reducing lifespan. With regard to the underlying cellular mechanisms, we found that MWCNT pre-exposure enhanced colony formation of Candida albicans in the body of nematodes, and suppressed innate immun... More

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