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Silencing of CCR7 inhibits the growth, invasion and migration of prostate cancer cells induced by VEGFC.

Int J Clin Exp Pathol.. 2015-10; 
Chi BJ, Du CL, Fu YF, Zhang YN, Wang RW.
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Mutagenesis Services ... The short small interfer- ing RNA (siRNA) was constructed by Nanjing Genscript Biotechnology Co., LTD with sequence specifically targeted to CCR7 gene: (5'- GAAGUGCAUACACCGAGAC- 3'). Transient trans- fection was performed using the Lipofectamine RNAi MAX reagent ... Get A Quote

摘要

Early in prostate cancer development, tumor cells express vascular endothelial growth factor C (VEGF-C), a secreted molecule that is important in angiogenesis progression. CC-chemokine receptor 7 (CCR7), another protein involved in angiogenesis, is strongly expressed in most human cancers, where it activated promotes tumor growth as well as favoring tumor cell invasion and migration. The present study aimed to investigate the effect of down-regulating CCR7 expression on the growth of human prostate cancer cells stimulated by VEGFC. The CCR7-specific small interfering RNA (siRNA) plasmid vector was constructed and then transfected into prostate cancer cells. The expression of CCR7 mRNA and protein was detected b... More

关键词

CCR7; Prostate cancer; VEGFC