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Megf10 Is a Receptor for C1Q That Mediates Clearance of Apoptotic Cells by Astrocytes.

J Neurosci.. 2016-05; 
Iram T, Ramirez-Ortiz Z, Byrne MH, Coleman UA, Kingery ND, Means TK, Frenkel D, El Khoury J.
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Mutagenesis Services ... directed mutagenesis experiments. Mutations C326R and C774R as described previously (Logan et al., 2011; Boyden et al., 2012) were introduced by site-directed mutagenesis (GenScript Mutagenesis Services). HEK-293T cells ... Get A Quote

摘要

Multiple EGF-like domains 10 (Megf10) is a class F scavenger receptor (SR-F3) expressed on astrocytes and myosatellite cells, and recessive mutations in humans result in early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD). Here we report that Megf10-deficient mice have increased apoptotic cells in the developing cerebellum and have impaired phagocytosis of apoptotic cells by astrocytes ex vivo We also report that cells transfected with Megf10 gain the ability to phagocytose apoptotic neurons and that Megf10 binds with high affinity to C1q, an eat-me signal for apoptotic cells. In contrast, cells expressing Megf10 with EMARDD mutations have impaired apoptotic cell clearance and impaired... More

关键词

C1q; EMARDD; MEGF10; apoptosis; astrocytes; clearance; scavenger receptor, SR-F3