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The In Vitro and In Vivo Response to MMP-Sensitive Poly (Ethylene Glycol) Hydrogels.

Ann Biomed Eng.. 2016-06; 
Amer LD, Bryant SJ.
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Catalog Products ... Hydrogels were formed from a pre-polymer solution containing 6% (g/g) 8-arm PEG-NB, and either PEG-dSH (MW 1000, Sigma) or a bis-cysteine crosslinker (CVPLS↓LYSGC) (GenScript) at a 0.5:1 thiol:ene ratio and 0.05% (g/g) photoinitiator (Irgacure 2959) in phosphate ... Get A Quote

摘要

Enzyme-sensitive hydrogels are a promising class of materials for cell encapsulation and tissue engineering because their ability to be degraded by cell-secreted factors. However, it is well known that nearly all synthetic biomaterials elicit a foreign body response (FBR) upon implantation. Therefore, this study aimed to evaluate the in vitro and in vivo response to an enzyme-sensitive hydrogel. Hydrogels were formed from poly(ethylene glycol) with the peptide crosslinker, C-VPLS↓LYSG-C, which is susceptible to matrix metalloproteinases 2 and 9. We evaluated the hydrogel by exogenously delivered enzymes, encapsulated mesenchymal stem cells as a tissue engineering relevant cell type, and by macrophage-secreted... More

关键词

Cell encapsulation; Enzyme-sensitive hydrogel; Foreign body response; Macrophage; Mesenchymal stem cell