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Urolithin A attenuates ox‐LDL induced endothelial dysfunction partly by modulating microRNA‐27 and ERK/PPAR‐γ pathway.

Mol Nutr Food Res.. 2016-09; 
Q Han, C Yan, L Wang, G Li, Y Xu, X Xia.
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Catalog Products ... Scientific Corporation, Waltham, MA, USA) and pre-miR-27 or miR-27 complementary 180 nucleotide (10 μM, GenScript Co., Ltd., Nanjing, China) were added into 100 μL of 181 Opti-MEM® Medium (Thermo Fisher Scientific Corporation, Waltham, MA, USA), 182 respectively. ... Get A Quote

摘要

SCOPE: Endothelial dysfunction and inflammation are both common events occurring during the development of atherosclerosis. Previous studies have shown that urolithins, the intestinal microflora metabolites of ellagitannin, exhibit anti-inflammation and antioxidative properties. This study aims to investigate the protective effect of urolithin A (UA) on ox-LDL-induced (where ox-LDL is oxidized low-density lipoprotein) endothelial dysfunction and possible modes of action. METHODS AND RESULTS: Human artery endothelial cells were incubated with 50 μg/mL ox-LDL and various concentrations of UA for 24 h. UA improved the productions of nitric oxide and endothelial nitric oxide synthase in a dose-dependent manner. ... More

关键词

Atherosclerosis; ERK signal pathway; Endothelial dysfunction; MicroRNA-27; Urolithin A