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Frequency of circulating topoisomerase-I-specific CD4 T cells predicts presence and progression of interstitial lung disease in scleroderma.

Arthritis Res Ther.. 2016-05; 
A Fava, R Cimbro, FM Wigley, QR Liu, A Rosen, F Boin
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Catalog Products ... stimulated for 18 hours using alternatively 1 ug/ml staphylococcal enterotoxin B (SEB)/ staphylococcal enterotoxin A (SEA), 15 ug/ml tetanus toxoid (TT) (NIBSC), 17 ug/ml human recombinant topoisomerase-I purified from baculovirus-infected insect cells (GenScript Biotech ... Get A Quote

摘要

BACKGROUND: Scleroderma is an antigen-driven T cell-mediated autoimmune disease. Presence of anti-topoisomerase-I antibodies is associated with pulmonary fibrosis and predicts increased mortality. Characterization of autoreactive T lymphocytes may shed light on disease pathogenesis and serve as a biomarker for disease activity. Here, we aimed to quantify and functionally characterize circulating topoisomerase I (topo-I)-specific CD4+ T cells and to define their association with presence and progression of interstitial lung disease (ILD) in patients with scleroderma. METHODS: Using flow cytometry, circulating topo-I-reactive CD4+ T cells were identified by the expression of specific activation markers (CD154 a... More

关键词

Autoantigen; Interstitial lung disease; Systemic sclerosis; T lymphocytes; Th17