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Temozolomide induces the expression of the glioma Big Potassium (gBK) ion channel, while inhibiting fascin-1 expression: Possible targets for glioma therapy.

Expert Opin Ther Targets.. 2016-10; 
Hoa NT,Ge L,Martini F,Chau V,Ahluwalia A,Kruse CA,Jadus MR115
Products/Services Used Details Operation
Monoclonal Antibody Services ... The primary antibodies included goat polyclonal antibody directed towards human gBK was made by GenScript Inc. (Piscataway, NJ).[25] The monoclonal antibody towards fascin-1 (sc-21743) was purchased from Santa Cruz Biotechnology (Dallas, TX). ... Get A Quote

摘要

OBJECTIVE: Temozolomide (TMZ) improves Glioblastoma Multiforme (GBM) patient survival. The invasive behavior of the glioma cells is the cause of GBM relapse. The glioma BK ion channel (gBK) may provide glioma cells with a mechanism to invade surrounding tissue. gBK contains epitopes that cytolytic T lymphocytes (CTLs) can recognize and kill glioma cells. Fascin-1 is an actin crosslinking molecule that supports microvilli; these membrane protrusions provide a physical defense against CTLs. TMZ was investigated to determine its effect on gBK and fascin-1 expression. RESEARCH DESIGN AND METHODS: Human glioma cells cultured in TMZ were analyzed for their altered mRNA and gBK protein levels by using quantitative r... More

关键词

Cytolytic T lymphocytes; TMZ; fascin-1; glioblastoma multiforme; glioma BK ion channel; microvilli; real time PCR; temozolomide