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New immunomodulatory role of neuropeptide Y (NPY) in Salmo salar leucocytes.

Dev Comp Immunol.. 2017-11; 
González-Stegmaier R,Villarroel-Espíndola F,Manríquez R,López M,Monrás M,Figueroa J,Enríquez R,Romero A.
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Catalog Products ... Each fish was given a one-time intraperitoneal injection of synthetic NPY (GenScript Corporation) at a concentration of 250 ng g −1 body weight, other group with 10 μg LPS/g body weight were administered respectively, and the control group with PBS, being used also as the ... Get A Quote

摘要

Neuropeptide Y (NPY) plays different roles in mammals such as: regulate food intake, memory retention, cardiovascular functions, and anxiety. It has also been shown in the modulation of chemotaxis, T lymphocyte differentiation, and leukocyte migration. In fish, NPY expression and functions have been studied but its immunomodulatory role remains undescribed. This study confirmed the expression and synthesis of NPY in S. salar under inflammation, and validated a commercial antibody for NPY detection in teleost. Additionally, immunomodulatory effects of NPY were assayed in vitro and in vivo. Phagocytosis and superoxide anion production in leukocytes and SHK cells were induced under stimulation with a synthetic ... More

关键词

Cytokines; Immunomodulation; Neuropeptide Y; Phagocytosis; Salmo salar