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Microcarriers with Synthetic Hydrogel Surfaces for Stem Cell Expansion.

Adv Healthc Mater.. 2017-08; 
Dias AD,Elicson JM,Murphy WL,.
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Catalog Products ... A solution of PEG-NB prepolymer (40 mg mL−1), PEG dithiol (3.4 kDa; Laysan Bio Inc., Arab, AL), and cyclic(RGDfC) (4 × 10−3 M; GenScript USA Inc., Piscataway, NJ) was prepared, assuming 60% cross-linking for a bulk hydrogel. … Get A Quote

摘要

Microcarriers are scalable support surfaces for cell growth that enable high levels of expansion, and are particularly relevant for expansion of human mesenchymal stem cells (hMSCs). The goal of this study is to develop a poly(ethylene glycol) (PEG)-based microcarrier coating for hMSC expansion. Commercially available microcarriers do not offer customizability of microcarrier surface properties, including elastic modulus and surface cell adhesion ligands. The lab has previously demonstrated that tuning these material properties on PEG-based hydrogels can modulate important cellular growth characteristics, such as cell attachment and expansion, which are important in microcarrier-based culture. Eosin-Y is adsorb... More

关键词

MSCs; biomanufacturing; cell therapies; microspheres; poly(ethylene glycol)