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Enhanced long-term potentiation in mature rats in a model of epileptic spasms with betamethasone-priming and postnatal N-methyl-D-aspartate administration.

Epilepsia.. 2016-03; 
Tsuji M, Takahashi Y, Watabe AM, Kato F.
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Catalog Products ... Drugs. Rat ACTH (1–39) was obtained from GenScript (Piscataway, NJ, USA). Betamethasone, NMDA, CNQX, and picrotoxin were purchased from Sigma-Aldrich (St. Louis, MO, USA). Other chemicals were purchased from Sigma-Aldrich and Nacalai-tesque (Kyoto, Japan). ... Get A Quote

摘要

OBJECTIVE: Patients with epileptic spasms are at high risk for learning and memory impairment later in life. We examined whether synaptic plasticity is affected in the adult hippocampus, a structure responsible for learning and memory, using an animal model of epileptic spasms of unknown cause. METHODS: We produced a rat model of N-methyl-d-aspartate (NMDA)-induced spasms combined with prenatal betamethasone administration. In 6- to 11-week-old rats, we evaluated the long-term potentiation (LTP) and general properties of synaptic transmission in pyramidal neurons in the CA1 area of the hippocampus in brain slices. RESULTS: The magnitude of LTP by theta burst stimulation was significantly larger in adult rats wi... More

关键词

Animal model; Epileptic spasms; Hippocampus; Long-term potentiation; Prenatal stress; Synaptic plasticity