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Activation of Mitochondrial Apoptosis and Regulation of Ceramide Signalling by COX-2 Inhibitors in Colon Cancer.

Transl Med.. 2015; 
SN Sanyal, Shelly Jain, Preety Ghanghas,Chandan Rana.
Products/Services Used Details Operation
TUNEL Universal Apoptosis Detection Kit ... Terminal deoxynucleotidyl transferase (TdT) dUTP Nick End Labelling (TUNEL) Assay Cells undergoing apoptosis were detected in paraffin embedded tissue sections (5 µm thick) by the TUNEL method, using TUNEL apoptosis detecting kit (GenScript, NJ, USA) according to ... Get A Quote

摘要

Bcl-2 family of proteins is implicated in the malignant tumors including colorectal cancer. Activation of Bcl-2 inhibits the pro-apoptotic proteins (Bax and Bad) and regulates many biological processes such as apoptosis, cell proliferation and cell growth. As the mitochondrial enzymes are involved in sphingolipid metabolism, it can regulate ceramide formation and in turn mitochondria play a central role for the regulation of ceramide induced apoptosis. Bcl-2/ BclxL activates sphingosine kinases (SKs), resulting in the accumulation of S1P (sphingosine-1-phosphate), thereby reducing apoptosis. In the present study, the anti-neoplastic effects have been observed of Etoricoxib and Celecoxib, two COX-2 selective non... More

关键词

Apoptosis; Bcl-2; Colorectal cancer; DMH; NSAIDs; SK-1