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Multiple solution structures of the disordered peptide indolicidin from IMS-MS analysis.

International Journal of Mass Spectrometry.. 2017-09; 
Neelam Khanal,Maissa M.Gaye,David E.Clemmer.
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Catalog Products ... feature in VMD [46]. 2.5. Sample preparation. Indolicidin extracted from bovine neutrophils ( > 95% purity) was purchased (GenScript USA Inc.; Piscataway, NJ) and used without further purification. Solution compositions ranged ... Get A Quote

摘要

The solution-favored conformations of the 13-residue disordered peptide, indolicidin (Ile1-Leu2-Pro3-Trp4-Lys5-Trp6-Pro7-Trp8-Trp9-Pro10-Trp11-Arg12-Arg13), are evaluated using electrospray ionization (ESI) coupled to ion mobility spectrometry-mass spectrometry (IMS-MS). The ESI-IMS-MS distributions for the dominant [M+4H]4+ ions indicate that three populations of structures coexist in a range of aqueous to non-aqueous solutions (water:dioxane, water:trifluoroethanol, and water:hexafluoroisopropanol). Conformer types and their relative abundances change in response to different solution environments suggesting that the gas phase conformers reflect on the solution populations present in different solvent environ... More

关键词

Disordered peptide;Ion mobility;Mass spectrometry;Cross section;Indolicidin;Antimicrobial structure;Conformation