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Hetero-Functionalized Gold Nanoparticles to Silence AU-Rich Element Containing mRNAs in RAGE-Expressing Inflammatory Cells: Preparation, Characterization, and In-Vitro Evaluation.

Journal of Nanoscience and Nanotechnology.. 2018-05; 
Mathialagan, Gokila Devi; Shanmugam, Narkunaraja.
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Catalog Products … 2. EXPERIMENTAL DETAILS aAuNPs 30 nm was purchased from NANOCS INC. Biotinylated ARE-siRNAfrom Dharmacon as described24 27 and biotinylated RIP from GenScript. DMEM medium and all other cell culture reagents were from Gibco-Invitrogen … Get A Quote

摘要

Diabetes, a chronic metabolic disorder associated with significantly accelerated rates of inflammation. Gold nanoparticle plays a crucial role in biomedical applications. We described the development of hetero-functionalized gold nanoparticles (hfAuNPs) for targeted selective gene silencing by RNAi interference. This hfAuNPs was developed by parallelly conjugating biotinylated ARE-siRNA (siRNA to Adenosine Uridine-rich elements) and biotinylated RAGE interacting-peptide (RIP) to streptavidin coated gold nanoparticles (aAuNPs) thus forms a complex that provides biocompatibility and functionality in a physiological environment. RIP can function as targeting agent and ARE-siRNA involve in silencing ARE containing ... More

关键词

ARE-siRNA; RAGE; RIP; aAuNPs; hfAuNPs