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Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: 2. Relationship to Aβ immunotherapy.

Alzheimers Dement.. 2017-07; 
Crane A, Brubaker WD, Johansson JU, Trigunaite A, Ceballos J, Bradt B, Glavis-Bloom C, Wallace TL, Tenner AJ, Rogers J.
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Catalog Products ... protocol. 2.2. Preparation of Ab Lyophilized Q5 human synthetic Ab(1–42) (GenScript, Pis- cataway, NJ) or FITC-conjugated Ab(1–42) (Bachem, Tor- rance, CA) was resuspended in sterile 100% DMSO (Sigma, St. Louis, MO ... Get A Quote

摘要

INTRODUCTION: Our previous studies have shown that amyloid β peptide (Aβ) is subject to complement-mediated clearance from the peripheral circulation, and that this mechanism is deficient in Alzheimer's disease. The mechanism should be enhanced by Aβ antibodies that form immune complexes (ICs) with Aβ, and therefore may be relevant to current Aβ immunotherapy approaches. METHODS: Multidisciplinary methods were employed to demonstrate enhanced complement-mediated capture of Aβ antibody immune complexes compared with Aβ alone in both erythrocytes and THP1-derived macrophages. RESULTS: Aβ antibodies dramatically increased complement activation and opsonization of Aβ, followed by commensurately enhanced A... More

关键词

Alzheimer's disease; Amyloid β peptide; Aβ immunotherapy; Blood; Complement; Complement receptor 1; Erythrocyte; Human; Macrophage