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A site-selective hyaluronan-interferonα2a conjugate for the treatment of ovarian cancer.

J Control Release.. 2016-08; 
Montagner IM, Merlo A, Carpanese D2, Dalla Pietà A2, Mero A3, Grigoletto A3, Loregian A4, Renier D5, Campisi M5, Zanovello P6, Pasut G7, Rosato A8.
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Catalog Products ... 2. Materials and methods. 2.1. Chemicals and drugs. Interferon-α2a (IFNα2a) was supplied by GenScript (Piscataway, USA), while hyaluronic acid sodium salt (HA, MW 200 kDa) was from Fidia Farmaceutici SpA (Abano Terme, Italy). ... Get A Quote

摘要

While interferon alpha (IFNα) is used in several viral and cancer contexts, its efficacy against ovarian cancer (OC) is far from being incontrovertibly demonstrated and, more importantly, is hindered by heavy systemic side effects. To overcome these issues, here we propose a strategy that allows a targeted delivery of the cytokine, by conjugating IFNα2a with an aldehyde-modified form of hyaluronic acid (HA). The resulting HA-IFNα2a bioconjugate was biochemically and biologically characterized. The conjugation with HA did not substantially modified both the antiviral function and the anti-proliferative activity of the cytokine. Moreover, the induction of STAT1 phosphorylation and of a specific gene expression... More

关键词

HAylation; Hyaluronan; Interferon; Ovarian cancer; Tumor targeting