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Lipoxin A4 protects against lipopolysaccharide-induced sepsis by promoting innate response activator B cells generation.

Int Immunopharmacol.. 2016-10; 
Cheng Q, Wang Z, Ma R, Chen Y, Yan Y, Miao S, Jiao J, Cheng X, Kong L, Ye D.
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Catalog Products ... Additional experiments were performed in which the mice were ip pretreated with the ALX/FPR2 antagonist Boc2 (Nt-butyloxycarbonyl-Phe-Leu-Phe-Leu-Phe) (10 μg/kg, GenScript). 2.3. Splenectomy. Splenectomy was carried out as previously described [25]. ... Get A Quote

摘要

Sepsis is a serious disease that leads to severe inflammation, dysregulation of immune system, multi-organ failure and death. Innate response activator (IRA) B cells, which produce granulocyte-macrophage colony-stimulating factor (GM-CSF), protect against microbial sepsis. Lipid mediator lipoxin A4 (LXA4) exerts anti-inflammatory and immunoregulatory effects, and it has been reported that LXA4 receptor ALX/FPR2 is expressed on B cells. Here, we investigated the potential role of LXA4 on IRA B cells in lipopolysaccharide (LPS)-induced sepsis. We found that LXA4 significantly promoted the expansion of splenic IRA B cells and increased GM-CSF expression in splenic B cells with LPS stimulation. After splenectomy, L... More

关键词

B cells; Granulocyte-macrophage colony-stimulating factor; Lipoxin A4; Sepsis; Signal transducer and activator of transcription 5