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The Role of Integrins α M β 2 (Mac-1, CD11b/CD18) and α D β 2 (CD11d/CD18) in Macrophage Fusion.

Am J Pathol.. 2016-08; 
Podolnikova NP, Kushchayeva YS, Wu Y, Faust J, Ugarova TP.
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Catalog Products ... Arizona. Materials, Reagents, and Cells. Permanox dishes and Permanox slide chambers were obtained from Nalge Nunc International (Rochester, NY). Murine IL-4 was purchased from GenScript (Piscataway, NJ). Monoclonal ... Get A Quote

摘要

The subfamily of β2 integrins is implicated in macrophage fusion, a hallmark of chronic inflammation. Among β2 family members, integrin Mac-1 (αMβ2, CD11b/CD18) is abundantly expressed on monocyte/macrophages and mediates critical adhesive reactions of these cells. However, the role of Mac-1 in macrophage fusion leading to the formation of multinucleated giant cells remains unclear. Moreover, the role of integrin αDβ2 (CD11d/CD18), a receptor with recognition specificity overlapping that of Mac-1, is unknown. We found that multinucleated giant cells are formed in the inflamed mouse peritoneum during the resolution phase of inflammation, and their numbers were approximately twofold higher in wild-type mice... More

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