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Functional Authentication of a Novel Gastropod Gonadotropin-Releasing Hormone Receptor Reveals Unusual Features and Evolutionary Insight.

PLoS One.. 2016-07; 
Kavanaugh SI, Tsai PS.
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Catalog Products ... Competitive binding properties of ap-GnRH and ap-AKH to the long and short isoforms of ap-GnRHR were examined using S2 cells transfected with pAWG-L or pAWG-S. Synthetic ap-GnRH (pQNYHFSNGWYA-amide; GenScript, Piscataway, NJ) was radioiodinated and ... Get A Quote

摘要

A gonadotropin-releasing hormone (GnRH)-like molecule was previously identified in a gastropod, Aplysia californica, and named ap-GnRH. In this study, we cloned the full-length cDNA of a putative ap-GnRH receptor (ap-GnRHR) and functionally authenticated this receptor as a bona fide ap-GnRHR. This receptor contains two potential translation start sites, each accompanied by a Kozak sequence, suggesting the translation of a long and a short form of the receptor is possible. The putative ap-GnRHR maintains the conserved structural motifs of GnRHR-like receptors and shares 45% sequence identity with the octopus GnRHR. The expression of the putative ap-GnRHR short form is ubiquitous in all tissues examined, whereas ... More

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