至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Screening of a composite library of clinically used drugs and well-characterized pharmacological compounds for cystathionine β-synthase inhibition identifies benserazide as a drug potentially suitable for repurposing for the experimental therapy of colon cancer.

Pharmacol Res.. 2016-11; 
Druzhyna N, Szczesny B, Olah G, Módis K, Asimakopoulou A, Pavlidou A4, Szoleczky P, Gerö D, Yanagi K, Törö G, López-García I, Myrianthopoulos V, Mikros E, Zatarain JR, Chao C, Papapetropoulos A, Hellmich MR7, Szabo C.
Products/Services Used Details Operation
Catalog Products ... dissolved freshly prior to each experiment. 2.2. Primary screen to identify inhibitors of CBS-derived H 2 production. Recombinant full length human CBS was purchased from Genscript Inc (Piscataway, NJ). The AzMC (7-azido-4 ... Get A Quote

摘要

Cystathionine-β-synthase (CBS) has been recently identified as a drug target for several forms of cancer. Currently no potent and selective CBS inhibitors are available. Using a composite collection of 8871 clinically used drugs and well-annotated pharmacological compounds (including the LOPAC library, the FDA Approved Drug Library, the NIH Clinical Collection, the New Prestwick Chemical Library, the US Drug Collection, the International Drug Collection, the 'Killer Plates' collection and a small custom collection of PLP-dependent enzyme inhibitors), we conducted an in vitro screen in order to identify inhibitors for CBS using a primary 7-azido-4-methylcoumarin (AzMc) screen to detect CBS-derived hydrogen sulf... More

关键词

Aminooxyacetic acid (PubChem CID:286); Aurintricarboxylic acid (PubChem CID:2259); Benserazide (PubChem CID:26964); Bioenergetics; Cancer; Cell proliferation; Hexachlorophene (PubChem CID: 3598); Hydrogen sulfide; NSC67078 (PubChem CID:66541); Nitric oxide; Tannic acid (PubChem CID:16129778)