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Adipocyte-secreted chemerin is processed to a variety of isoforms and influences MMP3 and chemokine secretion through an NFkB-dependent mechanism.

Mol Cell Endocrinol.. 2016-11; 
Dranse HJ, Muruganandan S, Fawcett JP, Sinal CJ.
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Catalog Products ... Lipopolysaccharide (LPS) and Bay11-7082 were obtained from Sigma Aldrich (Oakville, ON). Dys10 was purchased from Genscript (Piscataway, NJ, USA). Animals: C57Bl/6 mice were obtained from the Jackson Laboratory (Bar Harbor, ME). ... Get A Quote

摘要

Obesity is associated with white adipose tissue (WAT) remodelling characterized by changes in cellular composition, size, and adipokine secretion. Levels of the adipokine chemerin are positively associated with obesity; however, the biological function of chemerin in WAT is poorly understood. We identified factors involved in WAT remodelling, including matrix metalloproteinase (Mmp)3 and chemokines (Ccl2, 3, 5, 7), as novel targets of chemerin signalling in mature adipocytes. Inhibition of chemerin signalling increased MMP activity and the recruitment of macrophages towards adipocyte-conditioned media. These effects were mediated through increases in NFkB signalling, suggesting that chemerin exerts an anti-infl... More

关键词

Adipocyte; Adipokine; Adipose remodelling; Chemerin; Inflammation; NFkB