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The Role of Twist1 Phosphorylation in Angiogenesis and Pulmonary Fibrosis.

Am J Respir Cell Mol Biol.. 2016-11; 
Mammoto T, Jiang A, Jiang E, Mammoto A.
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Monoclonal Antibody Services ... Louis, MO). Anti-GAPDH monoclonal antibody was from Millipore (Billerica, MA). Anti-vimentin monoclonal antibody was from NeoMarkers (Fremont, CA). Anti-phosphoserine Twist1 (Ser42) antibody was created by GenScript (Piscataway, NJ). ... Get A Quote

摘要

Idiopathic pulmonary fibrosis is a chronic and progressive lung disease in which microvessel remodeling is deregulated. However, the mechanism by which deregulated angiogenesis contributes to the pathogenesis of pulmonary fibrosis remains unclear. Here we show that a transcription factor, Twist1, controls angiogenesis through the angiopoietin-Tie2 pathway, and that deregulation of this mechanism mediates pathological angiogenesis and collagen deposition in a bleomycin-induced mouse pulmonary fibrosis model. Twist1 knockdown decreases Tie2 expression and attenuates endothelial cell sprouting in vitro. Angiogenesis is also inhibited in fibrin gel implanted on Tie2-specific Twist1 conditional knockout (Twist1fl/fl... More

关键词

Tie2; Twist1; angiogenesis; phosphorylation; pulmonary fibrosis