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BML-111 equilibrated ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis to protect hepatic fibrosis in rats.

Prostaglandins Other Lipid Mediat.. 2017-07; 
Hu Q, Hu Z, Chen Q, Huang Y, Mao Z, Xu F, Zhou X.
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Catalog Products ... 2. Material and Methods. 2.1. Reagents. BML-111 was purchased from Cayman Chemical Company (Michigan, USA). BOC-2 was from GenScript Company(NJ, USA). CCL 4 was the product of Sigma Chemical Company (St. Louis, MO, USA). ... Get A Quote

摘要

BACKGROUND: It was recently reported Lipoxins (LXs) had protective effects on fibrous diseases, and renin-angiotensin-aldosterone system (RAAS) had played vital and bidirectional roles in hepatic fibrosis. In this paper, a hepatic fibrosis model, induced by carbon tetrachloride (CCL4) in rats, was used to observe the relations between RAAS and LXs, as well as to further explore the alternative anti-fibrosis mechanisms of LXs. METHODS: The model was evaluated by morphological observations and biochemical assays. The activities and contents of angiotensin converting enzyme (ACE) and angiotensin converting enzyme 2 (ACE2) were examined through assay kits and ELISA. The expression levels of angiotensinII (AngII)... More

关键词

Hepatic fibrosis; Lipoxins; Raas