至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Vibrio vulnificus MARTX cytotoxin causes inactivation of phagocytosis-related signaling molecules in macrophages.

J Biomed Sci.. 2017-08; 
Chen CL, Chien SC, Leu TH, Harn HI, Tang MJ, Hor LI.
Products/Services Used Details Operation
Catalog Products ... The Abs against Pyk2, Pyk2 Pi-Y402, SFKs, PI3K p85 Pi-Y458/p55 Pi-Y199, Akt, Akt Pi-S473, p38 and p38 Pi-T180/Y182 were purchased from Cell Signaling Technology. Abs against FAK Pi-Y861 and PI3K p85 were purchased from GenScript. ... Get A Quote

摘要

BACKGROUND: Vibrio vulnificus is a marine bacterial species that causes opportunistic infections manifested by serious skin lesions and fulminant septicemia in humans. We have previously shown that the multifunctional autoprocessing repeats in toxin (MARTXVv1) of a biotype 1 V. vulnificus strain promotes survival of this organism in the host by preventing it from engulfment by the phagocytes. The purpose of this study was to further explore how MARTXVv1 inhibits phagocytosis of this microorganism by the macrophage. METHODS: We compared between a wild-type V. vulnificus strain and its MARTXVv1-deficient mutant for a variety of phagocytosis-related responses, including morphological change and activation of signa... More

关键词

Antiphagocytosis; Cell rounding; Domain-deletion mutants; MARTX; Signaling pathway; Vibrio vulnificus