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Elimination or neutralization of endogenous high molecular weight FGF2 mitigates Doxorubicin induced cardiotoxicity.

Am J Physiol Heart Circ Physiol.. 2018-11; 
Koleini N, Santiago JJ, Nickel BE, Sequiera GL, Wang J, Fandrich RR, Jassal DS, Dhingra S, Kirshenbaum LA, Cattini PA, Kardami E.
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Monoclonal Antibody Services ...Rabbit anti-Hi-FGF2 antibodies (Hi-Ab) were made against a sequence unique to the amino-terminal extension of human Hi-FGF2 and affinity purified by <b>Genscript</b>... Get A Quote

摘要

Cardiac FGF2 is exerting multiple paracrine activities related to cardiac response to injury. Endogenous FGF2 is composed of a mixture of 70% high (Hi-) and 30% low (Lo-) molecular weight isoforms; while exogenously added Lo-FGF2 is cardioprotective, the role of endogenous Hi- or Lo- FGF2 is not well defined. Therefore, we investigated the effect of eliminating Hi-FGF2 expression on susceptibility to acute cardiac damage in vivo, caused by an injection of the genotoxic drug Doxorubicin (Dox). Mice genetically depleted of endogenous Hi-FGF2 and expressing only Lo-FGF2 (FGF2(Lo) mice), were protected from the Dox-induced decline in ejection fraction displayed by their wild-type FGF2(WT) mouse counterparts, regard... More

关键词

Doxorubicin induced cardiac damage; Drug-induced cardiotoxicity; FGF2 isoforms; High molecular weight FGF2; neutralizing antibody treatment