至今,GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次,处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果,再次证明GenScript 有能力帮助业内科学家Make research easy.

Autocleavage of the paracaspase MALT1 at Arg-781 attenuates NF-κB signaling and regulates the growth of activated B-cell like diffuse large B-cell lymphoma cells.

PLoS ONE. 2018; 
WuChun-Hsien,YangYu-Hsuan,ChenMei-Ru,TsaiChing-Hwa,ChengAnn-Lii,DoongShin-
Products/Services Used Details Operation
ORF cDNA Clones/MolecularCloud … (Rockville, Maryland). pcDNA3.1 + /C-(k)DYk-MALT1B [containing full length isoform B (813 aa) MALT1 cDNA] was purchased from GenScript (Piscataway, NJ). Schematic representation of all MALT1 variants was shown in S1 Fig … Get A Quote

摘要

MALT1 controls several receptors-mediated signaling to nuclear factor κB (NF-κB) through both its scaffold and protease function. MALT1 protease activity is shown to inactivate several negative regulators of NF-κB signaling and augment NF-κB activation ability. In this study, MALT1 was demonstrated to autoprocess itself in the presence of oligomerization-competent BCL10. Cleavage occurred after Arginine 781 located in the C-terminus of MALT1. Shortened MALT1 cleavage products showed attenuated binding ability with TRAF6. Its NF-κB activation ability was also weakened. Various MALT1 constructs including wild type, catalytically-inactive (MALT1_C464A), cleavage-defective (MALT1_R781L), or truncated (... More

关键词