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Additive effect of metastamiR-193b and breast cancer metastasis suppressor 1 as an anti-metastatic strategy.

Breast Cancer. 2018-10; 
HashemiZahra Sadat,Forouzandeh MoghadamMehdi,KhaliliSaeed,GhavamiMahlegha,SalimiFatemeh,SadroddinyEsm
Products/Services Used Details Operation
ORF cDNA Clones/MolecularCloud … buffer, they were annealed and cloned into pcDNA (pc/GFP/miR- 193b abbreviated: pc/GFP/193) (Supplementary 1). With the intention of reaching the highest possible level of expres- sion, the BRMS1 gene sequence has been optimized by GenScript (Genscript Corporation … Get A Quote

摘要

It has been reported that enhancing the cellular levels of miR-193b as well as breast cancer-metastasis-suppressor-1 (BRMS1) protein is associated with diminished metastatic characteristics in breast cancer. In view of these facts, as a new therapeutic intervention, we employed a restoration-based strategy using both miR-193b-3p mimic and optimized BRMS1 in the context of a chimeric construct.

关键词

BRMS1,Breast cancer metastasis,miR-193b